Results 251 to 260 of about 329,145 (275)
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Chromatin looping and the probability of transcription
Trends in Genetics, 2006Recent studies of several multigene clusters have shown that gene activation by a remote enhancer is associated with chromatin loop formation. It is not fully understood how a chromatin loop forms in a nucleus or how it is involved in gene regulation. In this article, we propose that the major feature that determines loop formation is the flexibility ...
Qiliang, Li +2 more
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ZNF143 is a regulator of chromatin loop
Cell Biology and Toxicology, 2018It is known that transcription factor ZNF143 frequently co-binds with CTCF-Cohesin complex in the anchor regions of chromatin loops. However, there is currently no genome-wide experiment to explore the functional roles of ZNF143 in chromatin loops. In this work, we used both computational and experimental analyses to investigate the regulatory effect ...
Zi Wen +3 more
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Closing the loops: chromatin loop dynamics after DNA damage
NucleusChromatin is a dynamic polymer in constant motion. These motions are heterogeneous between cells and within individual cell nuclei and are profoundly altered in response to DNA damage. The shifts in chromatin motions following genomic insults depend on the temporal and physical scales considered. They are also distinct in damaged and undamaged regions.
Kerry Bloom +2 more
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Polycomb-mediated chromatin loops revealed by a subkilobase-resolution chromatin interaction map
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance Chromatin loops, detected by chemical cross-linking and DNA sequencing, are frequently bounded by the polycomb repressive complex 1 in Drosophila .
Roger Kornberg +2 more
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R loops regulate promoter-proximal chromatin architecture and cellular differentiation
Nature Structural and Molecular Biology, 2015 Numerous chromatin-remodeling factors are regulated by interactions with RNA, although the contexts and functions of RNA binding are poorly understood.
Thomas Fazzio +2 more
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Re-defining the chromatin loop domain
Cytogenetic and Genome Research, 2001It is commonly accepted that the loop domain represents the basic structural unit of eukaryotic chromatin associated with DNA replication, gene expression and higher order packaging. However, molecular-cytological information defining the loop domain is lacking. There are gaps in our knowledge of the loop structure and how it regulates gene expression.
H H, Heng +5 more
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The role of chromatin loop extrusion in antibody diversification
Nature Reviews Immunology, 2022Cohesin mediates chromatin loop formation across the genome by extruding chromatin between convergently oriented CTCF-binding elements. Recent studies indicate that cohesin-mediated loop extrusion in developing B cells presents immunoglobulin heavy chain (Igh) variable (V), diversity (D) and joining (J) gene segments to RAG endonuclease through a ...
Yu Zhang +4 more
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Analysis of Chromatin Interaction and Accessibility by Trac-Looping
2023Spatial organization of the genome modulates pivotal biological processes. The emerging new technologies have provided novel insights into genome structure and its role in regulating cell activities. To examine the genome-wide chromatin interactions at accessible chromatin regions, we developed a DNA transposase-mediated analysis of chromatin looping ...
Shuai, Liu, Qingsong, Tang, Keji, Zhao
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Chromatin loops facilitate co-regulation of paralogues
Nature Reviews GeneticsHenry Ertl
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