Results 101 to 110 of about 3,249,481 (296)

Chromatin organization in the female mouse brain fluctuates across the oestrous cycle

Nature Communications, 2019
The molecular mechanisms underlying the dynamic nature of the female brain structure and function remain poorly understood. Here the authors characterise chromatin organization in the mouse female ventral hippocampus, finding it fluctuates with the ...
Ivana Jaric, Devin Rocks, John M. Greally, Masako Suzuki, Marija Kundakovic   +4 more
doaj   +1 more source

GBS‐MeDIP: A method for the simultaneous identification of genetic and epigenetic variants in tumors

FEBS Open Bio, EarlyView.
GBS‐MeDIP combines DNA sequencing with enrichment of methylated DNA to profile genetic and epigenetic variation in the same reduced genomic fraction. Applied to gastric cancer and parathyroid tumors, it identifies sequence variants, copy number changes, and differentially methylated regions together, helping distinguish true epigenetic changes from ...
Fábio Pértille, Shiva Rezaei, Julia Uffenorde, Oliver Gimm, Mohammad Ali Hosseinpour Feizi, Luiz Lehmann Coutinho, Carlos Guerrero‐Bosagna   +6 more
wiley   +1 more source

Revealing chromatin organization in metaphase chromosomes

, 2019
The local structural organization of chromatin in mitotic chromosomes is not well understood. A new cryo-electron tomography study from the Daban laboratory (Chicano et al, ) reveals that mitotic chromatin isolated from human cells can assume a plate ...
Fierz, Beat, Fierz B, Beat Fierz
core   +1 more source

The Fun30 chromatin remodeler Fft3 controls nuclear organization and chromatin structure of insulators and subtelomeres in fission yeast.

PLoS Genetics, 2015
In eukaryotic cells, local chromatin structure and chromatin organization in the nucleus both influence transcriptional regulation. At the local level, the Fun30 chromatin remodeler Fft3 is essential for maintaining proper chromatin structure at ...
Babett Steglich, Annelie Strålfors, Olga Khorosjutina, Jenna Persson, Agata Smialowska, Jean-Paul Javerzat, Karl Ekwall   +6 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Race and Household Income Are Associated With Disease Outcomes in Pediatric Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Hospitalized in the United States

Arthritis Care &Research, EarlyView.
Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos, William Daniel Soulsby III, Emily von Scheven   +2 more
wiley   +1 more source

3C (Chromatin Conformation Capture); A Technique to Study Chromatin Organization

, 2012
3C (chromatin conformation capture) is a technique to analyze chromatin organization in nuclei of eu-karyotic cells. The procedure of 3C includes the formaldehyde treatment of cells to fix interactions be-tween proteins and between proteins and DNA in ...
Yea Woon Kim, Aeri Kim
core  

Nuclear factor I genomic binding associates with chromatin boundaries [PDF]

, 2013
BACKGROUND: The Nuclear Factor I (NFI) family of DNA binding proteins (also called CCAAT box transcription factors or CTF) is involved in both DNA replication and gene expression regulation.
Armelle Gaussin, Schmid, Christoph D., Mermod, Nicolas, Jozef Adamcik, Ambrosini, Giovanna, Schmid, C. D., Pjanic, P., Giovanna Ambrosini, Plasari, Genta, Genta Plasari, Bucher, P., Adamcik, Jozef, Kerschgens, J., Christoph D Schmid, Petar Pjanic, Pjanic, Petar, Kerschgens, Jan, Ambrosini, G., Pjanic, Milos, Gaussin, Armelle, Gaussin, A., Pjanic, M., Philipp Bucher, Plasari, G., Jan Kerschgens, Adamcik, J., Giovani Dietler, Bucher, Philipp, Milos Pjanic, Dietler, Giovani, Dietler, G., Schmid, C.D., Nicolas Mermod, Mermod, N., Ambrosini G, Adamcik J, Plasari G, Dietler G, Pjanic P, Gaussin A, Bucher P, Schmid CD, Kerschgens J, Pjanic M, Mermod N   +44 more
core   +2 more sources

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

VEZF1 elements mediate protection from DNA methylation [PDF]

, 2010
There is growing consensus that genome organization and long-range gene regulation involves partitioning of the genome into domains of distinct epigenetic chromatin states.
Gowher Humaira, Hair, Alan, Miklos Gaszner, West Adam G., Gary Felsenfeld, Jacqueline Dickson, Dickson Jacqueline, Strogantsev, Ruslan, Gaszner Miklos, Dickson, Jacqueline, Adam G West, Humaira Gowher, Gaszner, Miklos, West, Adam G, Gowher, Humaira, West, Adam G., Felsenfeld Gary, Ruslan Strogantsev, Strogantsev Ruslan, Hair Alan, Felsenfeld, Gary, Alan Hair   +21 more
core   +2 more sources