Results 81 to 90 of about 3,249,481 (296)
The nuclear pore complex : its role in chromatin structure and RNA export [PDF]
, 2015 Epigenetic regulation of gene expression is a relatively new and rapidly developing research field. It studies the mechanisms of regulation of gene expression, which although heritable, occur independently of changes in the DNA sequence and certainly aid
Hristova, Emilia
core +1 more source
From compartments to loops: understanding the unique chromatin organization in neuronal cells
Epigenetics & ChromatinThe three-dimensional organization of the genome plays a central role in the regulation of cellular functions, particularly in the human brain. This review explores the intricacies of chromatin organization, highlighting the distinct structural patterns ...
Diana Zagirova +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
CTCF, Cohesin, and Chromatin in Human Cancer [PDF]
Genomics & Informatics, 2017 It is becoming increasingly clear that eukaryotic genomes are subjected to higher-order chromatin organization by the CCCTC-binding factor/cohesin complex.
Sang-Hyun Song, Tae-You Kim
doaj +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Chromatin Expansion Microscopy Reveals Nanoscale Organization of Transcription and Chromatin
, 2023 Nanoscale chromatin organization regulates gene expression. While chromatin is dramatically reprogrammed during zygotic genome activation (ZGA), the organization of chromatin regulatory factors during this universal process remains unclear.
Pownall, Mark
core +1 more source
Chromatin Organization in E.coli [PDF]
Biophysical Journal, 2009 Prokaryotic organisms must strike a balance between DNA accessibility and condensation: facilitating the genetic processes of transcription, replication, and DNA repair while simultaneously enabling the structural and physical processes of chromosome condensation and segregation in rapidly dividing cells.
Wiggins, Paul +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
Capturing native interactions: intrinsic methods to study chromatin conformation
Molecular Systems Biology, 2016 The 3D organization of chromatin controls gene expression through spatial interactions between genomic loci. FISH and 3C‐based methods that are commonly used to study chromatin organization utilize chemical crosslinking, a step that may introduce biases ...
M Jordan Rowley, Victor G Corces
doaj +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source