Results 221 to 230 of about 3,249,481 (296)

Astrocytic Ketogenesis Protects Central Nervous System Injury via CPT1A Stabilization and Epigenetic Regulation

Advanced Science, EarlyView.
A distinct astrocyte subpopulation, enriched at the lesion border, drives CNS repair through enhanced ketone body metabolism. This process promotes neuronal survival and axonal sparing via CPT1A stabilization and H3K9bhb‐dependent epigenetic reprogramming, positioning astrocytic ketogenesis as a promising therapeutic target for tissue regeneration ...
Dishui Pan, Haoming Shu, Rui Gao, Yilong Ren, Wu Ye, Xuhui Ge, Yao Gu, Yufeng Zhu, Xiaokun Wang, Honglin Teng, Xuhui Zhou, Wei Liu, Yang Gao, Jianquan Zhao, Weihua Cai   +14 more
wiley   +1 more source

Pre-established ATF4 occupancy and chromatin organization instruct selective transcription activation during integrated stress response. [PDF]

Nat Commun
Jiang P, Bian Q.
europepmc   +1 more source

Pyruvate Kinase M2‐Mediated H3K9 Lactylation and XBP1 Signaling Positive Feedback Loop Facilitates CD4+ T Cell Spinal Recruitment and Central Sensitization in Rheumatoid Arthritis

Advanced Science, EarlyView.
In collagen‐induced arthritis (CIA) mice, increased CD4+ T cell accumulation in the spinal dorsal horn induces pain hypersensitivity. Mechanistically, PKM2‐mediated H3K9 lactylation and XBP1 signaling positive feedback loop facilitates CD4+ T cell spinal migration and induces central sensitization‐like behaviors in CIA mice.
Yuepeng Jiang, Xiaoxuan Zhao, Xiao Ma, Mengjia Zheng, Junjun Wen, Yujie Li, Yue Wu, Yun Zhang, Jie Yu, Charles R. Ashby Jr, Chengping Wen   +10 more
wiley   +1 more source

Hierarchical Prediction and Perturbation of Chromatin Organization Reveal How Loop Domains Mediate Higher-Order Architectures. [PDF]

Adv Sci (Weinh)
Wei J, Xue Y, Gao YQ.
europepmc   +1 more source

Gapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir

Advanced Science, EarlyView.
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang, Sheng Zhang, Linxia Ouyang, Xin Du, Xin Huang, Zhilin Wang, Huixian Xie, Jiale Tang, Liyi Lou, Wenqing Ling, Weihao Wang, Jiang Zhou, Zhen Liu, Yibo Hu, Fuwen Wei, Guangping Huang   +15 more
wiley   +1 more source

The effects of Non3 mutations on chromatin organization in Drosophila melanogaster. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Yushkova AA, Ogienko AA, Andreyeva EN, Pindyurin AV, Letiagina AE, Omelina ES.   +5 more
europepmc   +1 more source

Histone Lactylation Drives WNK1 Expression to Promote Esophageal Squamous Cell Carcinoma Progression Through Histone H3 Ser10 Phosphorylation

Advanced Science, EarlyView.
In brief. Yan et al. demonstrated that the excess lactate produced by the enhanced glycolysis pathway in esophageal cancer can lactylate H3K23, H3K23la can be enriched in the WNK1 promoter region to promote WNK1 expression, thereby increasing the phosphorylation of the p‐H3 Ser10 site, and p‐H3S10 can be enriched in the AKT1 promoter region to promote ...
Mingyang Yan, Shaobo Fang, Yanming Song, Lei Zhang, Kexin Zhao, Zhenwei Wang, Yang Shao, Meng Liu, Xinyang Jia, Qinxin Guo, Mee‐Hyun Lee, Guoguo Jin, Zigang Dong   +12 more
wiley   +1 more source

Changes in 3D Chromatin Organization Drive Topologically Determined Gene Expression in the Poststroke Mouse Cortex. [PDF]

Stroke
Patel A, Dharap A.
europepmc   +1 more source

A Novel Immunosuppressive Effector Functions as a Bio‐Adjuvant to Enhance the Activity of Bacillus Thuringiensis and Chemical Insecticides

Advanced Science, EarlyView.
A previously unrecognized link between quorum sensing and host immune suppression is revealed in Bacillus thuringiensis(Bt). The PlcR‐PapR system induces the novel immunosuppressive effector PisP, which inhibits DAF‐16 nuclear translocation and downstream immune defenses, thereby promoting Bt pathogenicity.
Zhiyu Liu, Feng Chen, Liting Wan, Li Chen, Bowen Zhang, Fanling Li, Haixin Luo, Lixu Li, Alejandra Bravo, Mario Soberón, Dadong Dai, Jinshui Zheng, Ming Sun, Kai Wang, Donghai Peng   +14 more
wiley   +1 more source

Testis-specific protein HSF5 is essential for proper chromatin organization and transcriptional reprogramming to drive pachynema progression. [PDF]

Zool Res
Luo CH, Fan ZW, Yu ZQ, Liu DL, Xu HR, Zhou SM, Zhu XJ, Liu HC, Shao LF, Li ZA, Xie C, Zhan JF, Sun F.   +12 more
europepmc   +1 more source