Results 231 to 240 of about 3,249,481 (296)

STRIDE: A Sequencing Depth Robust Metric for Sparse Chromosome Conformation Capture Data Comparison

Advanced Science, EarlyView.
A mean first passage time (MFPT)‐based representation transforms sparse Hi‐C contact maps into robust topological representations, preserving biologically meaningful chromatin features and facilitating robust analysis of TADs, chromatin loops, differential chromatin contacts, and sparse single‐cell Hi‐C data.
Bingxiang Xu, Xiaomeng Gao, Weichu Tao, Zhihua Zhang, Feifei Li   +4 more
wiley   +1 more source

The insulator EACBE regulates V(D)J recombination of Tcrd gene by modulating chromatin organization. [PDF]

Front Immunol
Zhu Y, Dai R, Zhao H, Luo J, Li K, Xue W, Qin L, Pan H, Liao S, Hao B.   +9 more
europepmc   +1 more source

Single‐Nucleus RNA Sequencing Identifies CREM as a Brake on Myofiber Hypertrophy in Chickens

Advanced Science, EarlyView.
Single‐nucleus RNA sequencing on 91 144 nuclei from postnatal chicken pectoralis major between fast‐growing broilers (FG) and slow‐growing layers (SG) identifies the transcriptional factor CREM as a novel brake of myofiber hypertrophy. Mechanistically, functional validation experiments confirm that CREM activates the promoter of JUN and CREM deletion ...
Shuang Gu, Xiyu Zhao, Zheyi Jiang, Chaoliang Wen, Chaoyi Wang, Qiulian Wang, Qiang Huang, Fangren Lan, Shenghui Wu, Junying Li, Congjiao Sun, Huadong Yin, Ning Yang   +12 more
wiley   +1 more source

Chromatin Organization Governs Transcriptional Response and Plasticity of Cancer Stem Cells. [PDF]

Adv Sci (Weinh)
Wang Y, Frederick J, Medina KI, Bartom ET, Almassalha LM, Zhang Y, Wodarcyk G, Huang H, Ye IC, Gong R, Dunton CL, Duval A, Gonzalez PC, Pritchard J, Carinato J, Topchu I, Li J, Ji Z, Adli M, Backman V, Matei D.   +20 more
europepmc   +1 more source

CKMT1 Counteracts VDAC1 Oligomerization‐Induced Neuronal Pyroptosis Through Steric Hindrance in Ischemic Stroke

Advanced Science, EarlyView.
CKMT1 inhibits VDAC1 oligomerization via a dual‐region mechanism: its NTD interacts with the VDAC1 C‐terminal domain, while residues 1–39 sterically hinder dimerization, thereby reducing mtDNA leakage and AIM2 inflammasome activation, suppressing neuronal pyroptosis and protecting against cerebral ischemic injury. ABSTRACT Ischemic stroke is one of the
Xiaoyu Wang, Sai Shi, Jianghui Wu, Jingge Zhang, Shuqin Li, Yuyan Hu, Haifeng Yin, Chenguang Zhao, Dong Ma, Xiaohui Xian, Lizhe Liu, Ling Zhao, Xiyun Liu, Zhikai Yu, Lihua Dong, Wenbin Li, Lingyan Zhang, Min Zhang   +17 more
wiley   +1 more source

Interplay of chromatin organization and mechanics of the cell nucleus. [PDF]

Biophys J
De Corato M, Gomez-Benito MJ.
europepmc   +1 more source

Hierarchical Organization of Biomaterials in the Formation of Photonic Nanostructures

Advanced Science, EarlyView.
Natural organisms create vibrant structural colors through precisely organized nanostructures formed under mild biological conditions. This review explores how cellulose, chitin, corneous beta‐protein, and melanin form complex nanostructures across molecular, mesoscale, and tissue levels.
Sangyeop Kim, Jihun Kang, Seunghwan Moon, Liliana D'Alba, Matthew D. Shawkey, Jong‐Souk Yeo   +5 more
wiley   +1 more source

ChromaFactor: Deconvolution of single-molecule chromatin organization with non-negative matrix factorization. [PDF]

PLoS Comput Biol
Gunsalus LM, Keiser MJ, Pollard KS.
europepmc   +1 more source

Cardiac Endothelial Enhancer RNA Tek‐e1 Restores Microvascular Homeostasis After Myocardial Infarction

Advanced Science, EarlyView.
Hypoxia‐induced KDM5A downregulation establishes a distinct endothelial repair programme, increasing H3K4me3 at the Tek promoter and intronic enhancer, enabling ISL1 to coordinately activate Tek transcription and induce enhancer‐RNA Tek‐e1. This cis‐regulatory RNA is essential for additional Tek/TIE2 induction through R‐loop formation and reinforced ...
Yang Lyu, Kun Yang, Yunzhi Ling, Jiahui Cheng, Jiaran Shi, Shiyu Hu, Changyi Zhou, Wei Wei, Hanchuan Chen, Xiang Wei, Zengru Wang, Zhi Xiong, Chenxi Yang, Su Zou, Rui Shen, Yuanyue Song, Gaofeng Zhang, Rifeng Gao, Kaiyang Lin, Yingjia Xu   +19 more
wiley   +1 more source

Spatiotemporal 3D chromatin organization across multiple brain regions during human fetal development. [PDF]

Cell Discov
Sun Y, Li M, Ning C, Gao L, Liu Z, Zhong S, Lv J, Ke Y, Wang X, Ma Q, Liu Z, Wu S, Yu H, Zhao F, Zhang J, Gong Q, Liu J, Wu Q, Wang X, Chen X.   +19 more
europepmc   +1 more source