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Comparative Analysis of Metazoan Chromatin Organization [PDF]

Nature, 2014
Genome function is dynamically regulated in part by chromatin, which consists of the histones, non-histone proteins and RNA molecules that package DNA.
Andreas Rechtsteiner, Manolis Kellis, William S. Noble   +2 more
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Diversification of chromatin organization in eukaryotes

Current Opinion in Cell Biology, 2022
Our knowledge of the chromatin landscape and its regulation was originally discovered using yeast and a limited number of animals models. A wealth of studies in model plants now strongly demonstrates the conservation of certain features while illuminating the diversification of others.
Bhagyshree Jamge, Frédéric Berger
openaire   +2 more sources

Extended chromatin fibers and chromatin organization

Biotechnic & Histochemistry, 2010
Studies of chromatin extensibility have revealed the flow of chromatin and DNA from cell nuclei and chromosomes in response to gravity or mechanical stretch following lysis by hypertonic saline and detergent solutions. Since this phenomenon was first reported, the technical methods by which extended chromatin fibers (ECFs) may be analyzed have been ...
M L S, Mello, A S, Moraes, B C, Vidal
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Mesoscale organization of the chromatin fiber

Current Opinion in Genetics & Development, 2020
The proper organization of the physical genome is essential to facilitate DNA-templated processes from transcription to replication to DNA repair. Genome-wide studies over the past two decades have provided us with a detailed understanding of the positions and modification states of nucleosomes across the genomes of many organisms, as well as an ...
Nils, Krietenstein, Oliver J, Rando
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Organization of interphase chromatin

Chromosoma, 2005
The organization of interphase chromatin spans many topics, ranging in scale from the molecular level to the whole nucleus, and its study requires a concomitant range of experimental approaches. In this review, we examine these approaches, the results they have generated, and the interfaces between them.
Rachel A, Horowitz-Scherer, Christopher L, Woodcock   +1 more
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Chromatin organization at meiosis

BioEssays, 1988
Abstract From 1956, when the complex ultrastructure of meiotic chromosomes was discovered, 1 until 1985, when the isolation of meiotic chromosome cores was reported, knowledge of the molecular structure of the meiotic chromosome was at best a dream. The dissection of meiotic
P B, Møens, R E, Pearlman
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Dynamic chromatin organization in the cell

Essays in Biochemistry, 2019
Abstract The organization and regulation of genomic DNA as nuclear chromatin is necessary for proper DNA function inside living eukaryotic cells. While this has been extensively explored, no true consensus is currently reached regarding the exact mechanism of chromatin organization.
Eloise I. Prieto, Kazuhiro Maeshima
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Chromatin organization: form to function

Current Opinion in Genetics & Development, 2013
Recent developments in technology have made it possible to create high resolution genome-wide maps of histone marks, DNA binding proteins and physical interactions along genomic regions. Chromatin features are found together in different combinations, dividing the genome up into domains with distinct functional properties.
Carolyn A. de Graaf, Bas van Steensel
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Chromatin organization and DNA damage

2022
Genomic DNA is organized three-dimensionally in the nucleus as chromatin. Recent accumulating evidence has demonstrated that chromatin organizes into numerous dynamic domains in higher eukaryotic cells, which act as functional units of the genome. These compacted domains facilitate DNA replication and gene regulation.
Katsuhiko, Minami, Shiori, Iida, Kazuhiro, Maeshima   +2 more
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Nucleosome positioning and chromatin organization

Current Opinion in Structural Biology, 2020
In our cells, DNA is folded and packed with the help of many proteins into chromatin whose basic unit is a nucleosome-DNA wrapped around octamer of histone proteins. The chain of nucleosomes is further folded and arranged into many layers and has a dynamic organization.
Jyotsana J Parmar, Ranjith Padinhateeri
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