Results 261 to 270 of about 3,249,481 (296)

Chromatin organization re-viewed

Trends in Cell Biology, 1995
The predominant view of chromatin structure is that the beaded chain of nucleosomes is folded into a symmetrical helical fibre. Recently, however, direct evidence from cryoelectron microscopy and other imaging techniques confirms a non-symmetrical organization, consistent with modelling based on the heterogeneity of linker DNA lengths.
C L, Woodcock, R A, Horowitz
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Chromatin Organization in the Mammalian Nucleus

2004
Mammalian cells package their DNA into chromatin and arrange it in the nucleus as chromosomes. In interphase cells chromosomes are organized in a radial distribution with the most gene-dense chromosomes toward the center of the nucleus. Gene transcription, replication, and repair are influenced by the underlying chromatin architecture, which in turn is
Nick, Gilbert, Susan, Gilchrist, Wendy A, Bickmore   +2 more
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Chromatin organization in red triangles

Nature Reviews Genetics, 2023
This journal club by Elisa Oricchio highlights two studies published in 2012, which used chromatin conformation capture methods to detect the formation of self-interacting chromatin regions, known as topologically associating domains (TADs).
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Chromatin organization in Entamoeba histolytica

Molecular and Biochemical Parasitology, 1991
The chromatin structure of Entamoeba histolytica was investigated. It was found that this protozoan organizes its chromatin in nucleosome-like particles 10 nm in diameter, but digestion of the chromatin with micrococcal nuclease did not render a regularly spaced DNA ladder in agarose gels.
H, Torres-Guerrero, D A, Peattie, I, Meza   +2 more
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Subunit organization of Euglena chromatin

Biochemical and Biophysical Research Communications, 1980
Abstract Digestion of Euglena nuclei or extracted chromatin with micrococcal nuclease results in the identification of a repeating structure. The DNA repeat size, analyzed on agarose and polyacrylamide gels, is found to be 225±13 base pairs. DNase I digestion produces a serie of fragments multiples of roughly 10 bases.
R, Magnaval, R, Valencia, J, Paoletti
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Organization of transcribed regions of chromatin

Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1978
Abstract The endonuclease DNase II preferentially attacks a limited and tissue-specific portion of chromosomal DNA. This material may be separated from the bulk of chromatin DNA by virtue of its solubility in 2 mM MgCl2. The Mg2+ soluble fraction forms a specific subset of DNA sequences and is enriched four to sevenfold in sequences ...
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Chromatin organization in nuclei of sea urchin embryos. Comparison with the chromatin organization of the sperm

Cell Differentiation, 1976
The chromatin in sea urchin embryo nuclei and that in sperm heads are both organized in nucleosomes but show marked differences when analyzed by endonuclease digestion. Sperm chromatin DNA appears to be totally organized in nucleosomes that are highly resistant to nuclease hydrolysis.
C, Spadafora, L, Noviello, G, Geraci
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Chromatin organization — The 30nm fiber

Experimental Cell Research, 2012
Despite over 30 years of work, the fundamental structure of eukaryotic chromatin remains controversial. Here, we review the roots of this controversy in disparities between results derived from studies of chromatin in nuclei, chromatin isolated from nuclei, and chromatin reconstituted from defined components.
Sergei A, Grigoryev, Christopher L, Woodcock   +1 more
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Chromatin Dynamics and Higher-Order Chromatin Organization

2012
The association of nuclear DNA with histones and other specialized proteins in eukaryotes creates a complex structure that is known as chromatin. Although, at its most basic level, chromatin consists of a seemingly monotonous succession of repeating units – the nucleosomes – chromatin structure as a whole is extremely heterogeneous.
Anette Zeilner, Paolo Piatti, Alexandra Lusser   +2 more
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Archaeal Chromatin Organization

2010
In the light microscope, archaea resemble bacteria, in that they are small, generally single-celled organisms devoid of overt subcellular organization. Their genomes (which range in size from 0.5 to ∼6 Mb) are found in condensed nucleoid structures, rather than within nuclei and so the archaea can be broadly classified as “prokaryotes”. As in bacteria,
Stephen D. Bell, Malcolm F. White
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