Results 101 to 110 of about 547,450 (338)
Xist RNA antagonizes the SWI/SNF chromatin remodeler BRG1 on the inactive X chromosome
Nature Structural & Molecular Biology, 2018 The noncoding RNA Xist recruits silencing factors to the inactive X chromosome (Xi) and facilitates re-organization of Xi structure. Here, we examine the mouse epigenomic landscape of Xi and assess how Xist alters chromatin accessibility.
Teddy Jégu +10 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Nature Communications, 2019 The Ep400 chromatin remodeler determines genomic distribution of variant histones. In the current study, the authors show that loss of Ep400 in Schwann cells leads to aberrant expression of developmental regulators, and a peripheral neuropathy phenotype.
Franziska Fröb +8 more
doaj +1 more source
CHD7 regulates otic lineage specification and hair cell differentiation in human inner ear organoids
Nature Communications, 2022 Mutations in the chromatin remodeler CHD7 cause CHARGE syndrome, affecting development of several organs including the inner ear. Here, the authors recapitulated pathogenesis of this disease with human inner ear organoids and found that CHD7 is ...
Jing Nie +3 more
doaj +1 more source
Nucleic Acids Research, 2017 Chd1 (Chromodomain Helicase DNA Binding Protein 1) is a conserved ATP-dependent chromatin remodeler that maintains the nucleosomal structure of chromatin, but the determinants of its specificity and its impact on gene expression are not well defined.
Yaelim Lee, Daechan Park, V. Iyer
semanticscholar +1 more source
Dietary polyphenols and chromatin remodeling
Critical Reviews in Food Science and Nutrition, 2017 Polyphenols are the most abundant phytochemicals in fruits, vegetables, and plant-derived beverages. Recent findings suggest that polyphenols display the ability to reverse adverse epigenetic regulation involved in pathological conditions, such as obesity, metabolic disorder, cardiovascular and neurodegenerative diseases, and various forms of cancer ...
Gian Luigi Russo +5 more
openaire +5 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
RNA-directed DNA methylation involves co-transcriptional small-RNA-guided slicing of polymerase V transcripts in Arabidopsis. [PDF]
, 2018 Small RNAs regulate chromatin modifications such as DNA methylation and gene silencing across eukaryotic genomes. In plants, RNA-directed DNA methylation (RdDM) requires 24-nucleotide small interfering RNAs (siRNAs) that bind to ARGONAUTE 4 (AGO4) and ...
Chory, Joanne +11 more
core +1 more source
ATP-dependent Remodeling of Chromatin
Cold Spring Harbor Symposia on Quantitative Biology, 1998 Peer ...
Wu, Carl +8 more
openaire +3 more sources
Chromatin remodeling and cancer, part II: ATP-dependent chromatin remodeling [PDF]
Trends in Molecular Medicine, 2007 Connections between perturbations that lie outside of our genome, that is, epigenetic alternations, and tumorigenesis have become increasingly apparent. Dynamic chromatin remodeling of the fundamental nucleosomal structure (covered in this review) or the covalent marks residing in the histone proteins that make up this structure (covered previously in ...
Gang G, Wang, C David, Allis, Ping, Chi
openaire +2 more sources