Results 111 to 120 of about 547,450 (338)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy. [PDF]

, 2013
Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a central role in pathological cardiac hypertrophy, but the mechanisms by which it modulates gene activity in the nucleus to mediate hypertrophic signaling remain unclear. Here, we report that
An, Woojin, Awad, Salma, Bai, Yan, Bers, Donald, Kedes, Larry, Kunhi, Muhammad, Little, Gillian H, Poizat, Coralie   +7 more
core   +1 more source

Versatile Roles of the Chromatin Remodeler CHD7 during Brain Development and Disease

Frontiers in Molecular Neuroscience, 2017
CHD7 (Chromo-Helicase-DNA binding protein 7) protein is an ATP-dependent chromatin remodeler. Heterozygous mutation of the CHD7 gene causes a severe congenital disease known as CHARGE syndrome.
Weijun Feng, Chunxuan Shao, Haikun Liu
semanticscholar   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Single-molecule imaging of SWI/SNF chromatin remodelers reveals bromodomain-mediated and cancer-mutants-specific landscape of multi-modal DNA-binding dynamics

Nature Communications
Despite their prevalent cancer implications, the in vivo dynamics of SWI/SNF chromatin remodelers and how misregulation of such dynamics underpins cancer remain poorly understood.
Wilfried Engl, Aliz Kunstar-Thomas, Siyi Chen, Woei Shyuan Ng, Hendrik Sielaff, Ziqing Winston Zhao   +5 more
doaj   +1 more source

Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability

Nature Communications, 2019
The conserved long noncoding RNA Chaserr is transcribed upstream of the chromatin remodeler Chd2. Here, using mouse genetics and high throughput assays, the authors show that Chaserr inhibits expression of Chd2 in cis and is required for postnatal mouse ...
Aviv Rom, Liliya Melamed, Noa Gil, Micah Jonathan Goldrich, Rotem Kadir, Matan Golan, Inbal Biton, Rotem Ben-Tov Perry, Igor Ulitsky   +8 more
doaj   +1 more source

Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology

Nature Communications, 2021
Members of the CHD chromatin remodeler family are implicated in human pathologies, however CHD6 remained poorly studied. Here, the authors show that CHD6 binds to and regulates autophagy and stress response genes across cell types.
Yulia Kargapolova, Rizwan Rehimi, Hülya Kayserili, Joanna Brühl, Konstantinos Sofiadis, Anne Zirkel, Spiros Palikyras, Athanasia Mizi, Yun Li, Gökhan Yigit, Alexander Hoischen, Stefan Frank, Nicole Russ, Jonathan Trautwein, Bregje van Bon, Christian Gilissen, Magdalena Laugsch, Eduardo Gade Gusmao, Natasa Josipovic, Janine Altmüller, Peter Nürnberg, Gernot Längst, Frank J. Kaiser, Erwan Watrin, Han Brunner, Alvaro Rada-Iglesias, Leo Kurian, Bernd Wollnik, Karim Bouazoune, Argyris Papantonis   +29 more
doaj   +1 more source

Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates [PDF]

, 2017
Nucleosomes are essential for proper chromatin organization and the maintenance of genome integrity. Histones are post-translationally modified and often evicted at sites of DNA breaks, facilitating the recruitment of repair factors.
A Aze, A Gruhler, A Gunjan, A Lafon, A Seeber, A Seeber, AJ Morrison, AN Boettiger, Andrew Seeber, Assaf Amitai, B Celona, B Hu, C Dietz, C Lemaître, C Liu, C Sommer, CB Gerhold, D Liang, D Sage, David Holcman, DH Lee, G Soria, H van Attikum, I Chiolo, J Miné-Hattab, J Poli, J Schindelin, J Strecker, J Torres-Rosell, Jan Eglinger, JS Verdaasdonk, LF Povirk, M Lisby, Mariya Kryzhanovska, Michael H Hauer, N Wiechens, P Pasero, PM Krawczyk, Ragna Sack, Raphael Thierry, SB Haase, Susan M Gasser, Tom Owen-Hughes, V Dion, V Dion, V Roukos, Vijender Singh, W Heinemeyer, X Chen, Y Sanchez   +49 more
core   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

ARID1A loss derepresses a group of human endogenous retrovirus-H loci to modulate BRD4-dependent transcription

Nature Communications, 2022
Here the authors show mutation of the BAF chromatin remodeler subunit ARID1A results in an ARID1B-dependent upregulation of HERVH, an ERV required for the pluripotency regulatory network.
Chunhong Yu, Xiaoyun Lei, Fang Chen, Song Mao, Lu Lv, Honglu Liu, Xueying Hu, Runhan Wang, Licong Shen, Na Zhang, Yang Meng, Yunfan Shen, Jiale Chen, Pishun Li, Shi Huang, Changwei Lin, Zhuohua Zhang, Kai Yuan   +17 more
doaj   +1 more source