Results 131 to 140 of about 547,450 (338)

Mechanisms of gene regulation by SRCAP and H2A.Z

Nature Communications
Discriminating regulatory functions of chromatin composition from those of chromatin-modifying complexes is a central problem in gene regulation. This question remains unexplored in the context of histone variants and their dedicated chromatin remodelers.
Armelle Tollenaere, Enes Ugur, Susanna Dalla Longa, Cédric Deluz, Devin Assenheimer, J. Christof M. Gebhardt, Heinrich Leonhardt, David M. Suter   +7 more
doaj   +1 more source

HP1 reshapes nucleosome core to promote phase separation of heterochromatin [PDF]

, 2019
Heterochromatin affects genome function at many levels. It enables heritable gene repression, maintains chromosome integrity and provides mechanical rigidity to the nucleus1,2.
Burlingame, AL, Dharmarajan, V, Griffin, PR, Gross, JD, Narlikar, GJ, Pascal, BD, Sanulli, S, Tibble, RW, Trnka, MJ   +8 more
core  

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Hepatitis Delta Virus histone mimicry drives the recruitment of chromatin remodelers for viral RNA replication

Nature Communications, 2020
Histone mimicry of viral components is a strategy to subvert host factors for virus replication. Here, the authors show that an acetylated histone-like motif of the small Hepatitis Delta Antigen (S-HDAg) interacts with the chromatin remodeler BAZ2B to ...
Natali Abeywickrama-Samarakoon, Jean-Claude Cortay, Camille Sureau, Susanne Müller, Dulce Alfaiate, Francesca Guerrieri, Apirat Chaikuad, Martin Schröder, Philippe Merle, Massimo Levrero, Paul Dény   +10 more
doaj   +1 more source

Taking into account nucleosomes for predicting gene expression [PDF]

, 2013
The eukaryotic genome is organized in a chain of nucleosomes that consist of 145-147. bp of DNA wrapped around a histone octamer protein core. Binding of transcription factors (TF) to nucleosomal DNA is frequently impeded, which makes it a challenging ...
Beshnova, DA, Erdel, F, Mallm, JP, Rippe, K, Teif, VB, Vainshtein, Y   +5 more
core   +1 more source

The chromatin remodeler DDM1 promotes hybrid vigor by regulating salicylic acid metabolism

Cell Discovery, 2016
In plants, hybrid vigor is influenced by genetic and epigenetic mechanisms; however, the molecular pathways are poorly understood. We investigated the potential contributions of epigenetic regulators to heterosis in Arabidposis and found that the ...
Qingzhu Zhang, Yanqiang Li, Tao Xu, A. Srivastava, Dong Wang, Liang Zeng, Lan Yang, Li He, Heng Zhang, Zhimin Zheng, Dong-Lei Yang, Cheng Zhao, Juan Dong, Z. Gong, Renyi Liu, Jian‐Kang Zhu   +15 more
semanticscholar   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

GATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler

Genome Biology, 2016
BackgroundTranscription factor-dependent cellular reprogramming is integral to normal development and is central to production of induced pluripotent stem cells.
Motoki Takaku, Sara A. Grimm, T. Shimbo, L. Perera, R. Menafra, H. Stunnenberg, T. Archer, Shinichi Machida, H. Kurumizaka, P. Wade   +9 more
semanticscholar   +1 more source

The Floor‐Ceiling‐Chip, or 2 × 2D = Pseudo‐3D—Approaching 3D Cell Morphology and Organization between Two Opposing 2D Substrates with Cell‐Adhesive Protein Micropatterns

Advanced Healthcare Materials, EarlyView.
Here, we present a novel 3D cell patterning and culture platform. The “Floor‐Ceiling‐Chip” (FC‐Chip) consists of two opposing track‐etched membranes, creating a pseudo‐3D microenvironment for the cells in between. By providing the membranes with micropatterned cell‐adhesive islands of varying geometries and sizes, the FC‐Chip enables control over cell ...
Urandelger Tuvshindorj, Francesca Giacomini, Esra Güben Kaçmaz, Tim ten Brink, Lorenzo Moroni, Zeinab Tahmasebi Birgani, Clemens van Blitterswijk, Pamela Habibović, Stefan Giselbrecht, Jan de Boer, Roman Truckenmüller   +10 more
wiley   +1 more source

ARID1A safeguards the canalization of the cell fate decision during osteoclastogenesis

Nature Communications
Chromatin remodeler ARID1A regulates gene transcription by modulating nucleosome positioning and chromatin accessibility. While ARID1A-mediated stage and lineage-restricted gene regulation during cell fate canalization remains unresolved.
Jiahui Du, Yili Liu, Jinrui Sun, Enhui Yao, Jingyi Xu, Xiaolin Wu, Ling Xu, Mingliang Zhou, Guangzheng Yang, Xinquan Jiang   +9 more
doaj   +1 more source