Results 141 to 150 of about 547,450 (338)

Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome [PDF]

, 2018
This work was funded by Wellcome Senior Fellowship 095062, Wellcome Trust grants 094090, 099149 and 097945. ALH was funded by an EMBO long term fellowship ALTF 380–2015 co-funded by the European Commission (LTFCOFUND2013, GA-2013–609409).ATP-dependent ...
Armache, Ayala, Barbera, Batta, Blosser, Bonnet, Chua, Clapier, Clapier, Côté, de Dieuleveult, Debelouchina, Deindl, Dürr, Elsässer, Eustermann, Farnung, Fei, Ferreira, Fierz, Flaus, Fleming, Gatchalian, Gibson, Gkikopoulos, Grüne, Gu, Hall, Hamiche, Hammond, Hauk, Hennig, Hwang, Jeschke, Kelley, Kizer, Krietenstein, Krogan, Lee, Lee, Leonard, Levendosky, Li, Li, Lia, Lin, Liu, Liu, Liu, Long, Luger, Lusser, Machida, Makde, Mayer, McGinty, McGinty, McKnight, Meng, Morgan, Moyal, Nakamura, Narlikar, Ngo, Nicholls, Nodelman, Ocampo, Parnell, Pavri, Pointner, Pokholok, Qiu, Racki, Radman-Livaja, Robinson, Robzyk, Ryan, Saha, Scheres, Schulze, Sharma, Shema-Yaacoby, Simic, Simon, Singleton, Sirinakis, Smolle, Stockdale, Sun, Sundaramoorthy, Thomä, Tokuda, Torigoe, Tran, Tsankov, Velankar, Vlaming, Waterhouse, Willhoft, Wilson, Wollmann, Wood, Wyce, Xiao, Yan, Yang, Zhang, Zhang, Zheng, Zofall   +109 more
core   +4 more sources

Engineering Extracellular Vesicle Production Through Magnetic Ion Channel Activation for Bone Regeneration

Advanced Healthcare Materials, EarlyView.
Magnetic Ion Channel Activation (MICA) enables remote stimulation of mechanosensitive ion channels using functionalised magnetic nanoparticles, enhancing extracellular vesicle (EV) biogenesis is pre‐osteoblasts. MICA desrived EVs exhibit typical nano‐vesicular characteristics but display superior pro‐osteogeneic activity, promoting mesenchymal stem ...
Afeesh Rajan Unnithan, Kenny Man, Kritika, Lee A. Gethings, Christopher J. Hughes, Alicia Keenan, Liam Heaney, Sophie C. Cox, Owen G. Davies, Alicia J. El Haj   +9 more
wiley   +1 more source

Investigating the Influence of CHD1 on Gene Expression in Drosophila Melanogaster Using Position Effect Variegation [PDF]

, 2015
Position Effect Variegation (PEV) is the mosaic expression of a gene that has been moved out of its optimal environment and into a different area on the chromosome.
Bui, Phuongngan Thi
core   +2 more sources

ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models

Advanced Healthcare Materials, EarlyView.
A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang, Zhengpeng Wan, Lei Wang, Caihong Wu, Junkai Zhang, Sarah Spitz, Xun Wang, Marie A. Floryan, Mark F. Coughlin, Francesca M. Pramotton, Liling Xu, Ron Weiss, Roger D. Kamm   +12 more
wiley   +1 more source

Chromatin remodeling and dna topology in transcription and genome stability [PDF]

, 2013
Eukaryotic DNA is wrapped around histone proteins to form nucleosomes, the fundamental repeati ng unit of chromatin. DNA packaging into chromatin both solves and creates problems. It allows the centimeters, or even meters, of DNA that constitute a
Persson, Jenna
core   +1 more source

Sequence-targeted nucleosome sliding in vivo by a hybrid Chd1 chromatin remodeler

Genome Research, 2016
ATP-dependent chromatin remodelers regulate chromatin dynamics by modifying nucleosome positions and occupancy. DNA-dependent processes such as replication and transcription rely on chromatin to faithfully regulate DNA accessibility, yet how chromatin ...
Jeffrey. N. McKnight, T. Tsukiyama, G. Bowman   +2 more
semanticscholar   +1 more source

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

The Arp8 and Arp4 module acts as a DNA sensor controlling INO80 chromatin remodeling

Nature Communications, 2018
INO80 chromatin remodeler plays important roles in transcription, DNA repair, recombination, and heterochromatin maintenance. Here the authors characterise the functional interplay between the actin-related proteins (Arps)  in INO80, showing that Arp8 ...
Sandipan Brahma, Mzwanele Ngubo, Somnath Paul, Maheshi Udugama, Blaine Bartholomew   +4 more
doaj   +1 more source

Common Signatures of Altered Gene Regulation and Invasiveness of Different Breast Cancer Cell Lines after Matrix Interface Crossing

Advanced Healthcare Materials, EarlyView.
Interface transmigration reprograms triple‐negative breast cancer cells, triggering a shared switch toward more aggressive and invasive phenotypes. Using a collagen I interface model, this study identifies shared transcriptional changes involving proliferation, chromatin remodeling, and DNA repair pathways.
Cornelia Clemens, Hannah Trampert, Nataliia Kotsiuba, Tilo Pompe   +3 more
wiley   +1 more source

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source