Results 151 to 160 of about 547,450 (338)

The Arabidopsis SWI2/SNF2 Chromatin Remodeler BRAHMA Regulates Polycomb Function during Vegetative Development and Directly Activates the Flowering Repressor Gene SVP

PLoS Genetics, 2015
The chromatin remodeler BRAHMA (BRM) is a Trithorax Group (TrxG) protein that antagonizes the functions of Polycomb Group (PcG) proteins in fly and mammals.
Chenlong Li, Chen Chen, Lei Gao, Songguang Yang, Vi Nguyen, Xuejiang Shi, K. Siminovitch, S. Kohalmi, Shangzhi Huang, Keqiang Wu, Xuemei Chen, Yuhai Cui   +11 more
semanticscholar   +1 more source

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

Characterising ISWI chromatin remodeler in Trypanosoma cruzi

Memorias do Instituto Oswaldo Cruz
BACKGROUND Imitation SWItch (ISWI) ATPase is the catalytic subunit in diverse chromatin remodeling complexes. These complexes modify histone-DNA interactions and therefore play a pivotal role in different DNA-dependent processes. In Trypanosoma cruzi, a
Yirys Díaz-Olmos, Michel Batista, Adriana Ludwig, Fabricio K Marchini   +3 more
doaj   +1 more source

The Fun30 Chromatin Remodeler Fft3 Controls Nuclear Organization and Chromatin Structure of Insulators and Subtelomeres in Fission Yeast

PLoS Genetics, 2015
In eukaryotic cells, local chromatin structure and chromatin organization in the nucleus both influence transcriptional regulation. At the local level, the Fun30 chromatin remodeler Fft3 is essential for maintaining proper chromatin structure at ...
Babett Steglich, Annelie Strålfors, Olga Khorosjutina, Jenna Persson, Agata Smialowska, J. Javerzat, K. Ekwall   +6 more
semanticscholar   +1 more source

Bottom‐Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues

Advanced Materials, EarlyView.
A bottom‐up biomaterial platform is developed to program transcriptomic states in pancreatic cancer organoids by tuning adhesion cues within synthetic matrices. By combining a Design of Experiments framework with multiobjective optimization, matrix compositions are identified that enrich specific cellular programs like EMT.
Ali Nadernezhad, Verena J. Kast, Dagmar Pette, Franziska Baenke, Daniel E. Stange, Carsten Werner, Daniela Loessner   +6 more
wiley   +1 more source

Matrix Viscoelasticity Regulates Dendritic Cell Migration and Immune Priming

Advanced Materials, EarlyView.
Matrix viscoelasticity is a key mechanical feature of the tumor microenvironment but remains poorly understood in immune regulation. Here, we develop a tunable collagen platform to decouple viscoelasticity from stiffness and show that slow‐relaxing matrices constrain dendritic cell migration by limiting actomyosin‐driven matrix remodeling, thereby ...
Wei‐Hung Jung, Emie Humann, Joshua M. Price, Yoav Binenbaum, Azra Haseki, Sanjana Iyer, David J. Mooney   +6 more
wiley   +1 more source

The CSB chromatin remodeler and CTCF architectural protein cooperate in response to oxidative stress

Nucleic Acids Research, 2015
Cockayne syndrome is a premature aging disease associated with numerous developmental and neurological abnormalities, and elevated levels of reactive oxygen species have been found in cells derived from Cockayne syndrome patients.
R. Lake, E. L. Boetefuer, Kyoung-Jae Won, Hua-Ying Fan   +3 more
semanticscholar   +1 more source

Bioelectrical Interfaces Beyond Excitable Cells: Cancer, Aging, and Gene Expression Modulation

Advanced Materials Interfaces, EarlyView.
ABSTRACT The investigation of biological conductivity has evolved from its classical foundation based on ionic fluxes underpinning cardiac and neuronal excitability to a multifaceted regulator of cellular physiology. Traditional approaches for probing electrical events in living matter focused largely on action potentials recording.
Paolo Cadinu, Matthew K. Burgess, Catarina Franco Jones, Marzia Iarossi, Manuel Schröter, Nako Nakatsuka, Mustafa B. A. Djamgoz, Gil Gonçalves, Sidahmed Abayzeed, Paola Sanjuán‐Alberte, Paula M. Mendes, Frankie J. Rawson, Malavika Nair, Michael Levin, Rosalia Moreddu   +14 more
wiley   +1 more source

Balancing noise and plasticity in gene expression [PDF]

, 2011
Coupling the control of expression stochasticity (noise) with the capacity to expression change (plasticity) can constrain gene function and limit adaptation. Which factors contribute then to modulate this coupling?
Djordje Bajic, Juan F. Poyatos
core   +1 more source

Topography‐Regulated Screening Platform for Myoblast Contact Guidance

Advanced Materials Technologies, EarlyView.
This study develops a topography‐regulated screening platform (12 gradients in 96‐topography‐well plate) enabling analysis of skeletal muscle morphogenesis. The topography‐induced cell morphology changed, cell polarization, and myotube differentiation, establishing an evaluative framework for generating pathologically relevant myotube phenotypes to ...
Tianqi Feng, Torben A.B. van der Boon, Savannah Amy Haupt, Adam Jones, Yanjing Ji, Theo G. Van Kooten, Patrick van Rijn   +6 more
wiley   +1 more source