Results 191 to 200 of about 547,450 (338)

Distortion of histone octamer core promotes nucleosome mobilization by a chromatin remodeler

Science, 2017
K. K. Sinha, J. Gross, G. Narlikar
semanticscholar   +1 more source

3D Chromatin Architecture Provides Insights Into Leaf Trait Variation Among Pear Species

Advanced Science, EarlyView.
ABSTRACT Three‐dimensional (3D) chromatin architecture plays a fundamental role in eukaryotic gene regulations, its functional significance in perennial fruit trees remains poorly characterized despite extensive applications in crop genomics. Here, we developed high‐resolution (∼5 kb) Hi‐C maps of Pyrus and compared 3D genomic architecture of three ...
Yueyuan Liu, Chenhui Han, Cheng Xue, Manyi Sun, Bobo Song, Yongsong Xue, Guangyan Yang, Shaozhuo Xu, Wei Wei, Jiaming Li, Runze Wang, Jun Wu   +11 more
wiley   +1 more source

All hands on DEK: structural insights into a unique histone modifier and chromatin remodeler. [PDF]

Epigenetics Chromatin
Peters EJ, Gardner KL, Privette Vinnedge LM.   +2 more
europepmc   +1 more source

The Conserved Chromatin Remodeler SMARCAD1 Interacts with TFIIIC and Architectural Proteins in Human and Mouse. [PDF]

Genes (Basel), 2023
Sachs P, Bergmaier P, Treutwein K, Mermoud JE.   +3 more
europepmc   +1 more source

Missense variants in the chromatin remodeler CHD1 are associated with neurodevelopmental disability

Journal of Medical Genetics, 2017
Genay O. Pilarowski, H. Vernon, Carolyn D. Applegate, Leandros Boukas, M. Cho, C. Gurnett, P. Benke, E. Beaver, Jennifer Heeley, L. Medne, I. Krantz, M. Azage, D. Niyazov, Lindsay B. Henderson, I. Wentzensen, B. Baskin, M. Sacoto, G. Bowman, H. Bjornsson   +18 more
semanticscholar   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Srcap Chromatin Remodeler Is Required for Efficient Replication Dynamics in Mammalian Cells. [PDF]

Int J Mol Sci
Dzhokova SK, Hristova RH, Botev PS, Guecheva TN, Gospodinov AG.   +4 more
europepmc   +1 more source

Expansion of the ISWI chromatin remodeler family with new active complexes

EMBO Reports, 2017
M. Oppikofer, Tianyi Bai, Y. Gan, B. Haley, Peter S. Liu, W. Sandoval, C. Ciferri, A. Cochran   +7 more
semanticscholar   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Chromatin remodeler BAF maintains HBV cccDNA transcriptional competence and represents a therapeutic target. [PDF]

Nucleic Acids Res
Huang D, Zheng Y, Deng E, Ji X, Zhang Y, Sun H, Chen Y, Yao Y, Zhou Y, Zhang M, Zhou Z, Chen Y, Su D, Fan X, Chen X, Pei R.   +15 more
europepmc   +1 more source