Results 211 to 220 of about 547,450 (338)

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Toxoplasma gondii chromatin remodeler SWI/SNF controls parasite division and gene expression. [PDF]

Nat Commun
Hu D, Li X, Huang J, Zou X, Si H, Suo X, Song X.   +6 more
europepmc   +1 more source

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source

Chromatin remodeler ISW-1 orchestrates chromosome axis assembly and meiotic progression in C. elegans. [PDF]

Nucleic Acids Res
Wang R, Sun Y, Kang J, Tian J, Wang S, Zhu Z, Zhao L, Qi F, Gao J.   +8 more
europepmc   +1 more source

Differentiation of Plasmodium male gametocytes is initiated by the recruitment of a chromatin remodeler to a male-specific cis-element. [PDF]

Proc Natl Acad Sci U S A, 2023
Kaneko I, Nishi T, Iwanaga S, Yuda M.
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

The Chromatin Remodeler Chd8 Regulates Hematopoietic Stem and Progenitor Cell Survival and Differentiation During Zebrafish Embryogenesis. [PDF]

Int J Mol Sci
Ahmed A, Wei X, Zhong D, Ullah R, Li W, Jing L.   +5 more
europepmc   +1 more source

Bi-directional nucleosome sliding by the Chd1 chromatin remodeler integrates intrinsic sequence-dependent and ATP-dependent nucleosome positioning. [PDF]

Nucleic Acids Res, 2023
Park S, Brandani GB, Ha T, Bowman GD.
europepmc   +1 more source

Influence of the chromatin remodeler ACF1 on the dynamic behaviour of 53BP1 foci after heavy ion irradiation [PDF]

, 2013
Becker, A., Becker, G., Durante, M., Jakob, B., Khan, R., Leifke, A. L., Taucher-Scholz, G.   +6 more
core  

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source