Results 231 to 240 of about 547,450 (338)

The CSB chromatin remodeler regulates PARP1- and PARP2-mediated single-strand break repair at actively transcribed DNA regions. [PDF]

Nucleic Acids Res, 2023
Bilkis R, Lake RJ, Cooper KL, Tomkinson A, Fan HY.   +4 more
europepmc   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Regulation of DNA translocation of chromatin remodeler enzyme Chd1 by exit DNA unwrapping. [PDF]

Life Metab
Tian Y, Jia Q, Li M, Sia Y, Hu P, Chen K, Li M, Li X, Xu Z, Ma L, Ye Y, Lu Y, Chen Z.   +12 more
europepmc   +1 more source

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source

Chromatin remodeler BRD9 represses transcription of PPARα target genes, including CPT1A to suppress lipid metabolism. [PDF]

J Lipid Res
Yokoseki I, Nakano M, Kurosawa K, Higuchi Y, Uehara S, Yoneda N, Suemizu H, Fukami T, Nakajima M.   +8 more
europepmc   +1 more source

De Novo Mutations in CHD4, an ATP-Dependent Chromatin Remodeler Gene, Cause an Intellectual Disability Syndrome with Distinctive Dysmorphisms.

American Journal of Human Genetics, 2016
K. Weiss, P. Terhal, L. Cohen, M. Bruccoleri, M. Irving, Ariel F. Martinez, J. Rosenfeld, Keren Machol, Yaping Yang, Pengfei Liu, M. Walkiewicz, J. Beuten, N. Gomez‐Ospina, Katrina M. Haude, C. Fong, G. Enns, J. Bernstein, Judith Fan, G. Gotway, Mohammad Ghorbani, K. V. van Gassen, G. Monroe, G. van Haaften, L. Basel‐Vanagaite, Xiang-Jiao Yang, Philippe M. Campeau, M. Muenke   +26 more
semanticscholar   +1 more source

Bioprinted Tumor Microenvironment Models Reveal Immune Evasion and Guide CAR‐NK Therapeutic Strategies

Advanced Science, EarlyView.
This study presents a 3D embedded bioprinting platform that recapitulates key stromal features of the tumor microenvironment using fibroblasts and lung‐derived ECM. The model enables functional assessment of CAR‐NK cells and provides a versatile tool to support the development of next‐generation immunotherapeutic strategies against solid tumors ...
Dahong Kim, Seona Jo, In‐Hwan Jang, Yu‐Jin Kim, Youngmee Jung, Junhyoung Ahn, Hyungjun Lim, Jae Jong Lee, Kangwon Lee, Tae‐Don Kim, Su A Park   +10 more
wiley   +1 more source

Fungal chromatin remodeler Isw1 modulates translation via regulating tRNA transcription. [PDF]

Nucleic Acids Res
Wang J, Zhang Y, Wang J, Wang L, Li B, Liu S, Sun X, Ma Z.   +7 more
europepmc   +1 more source

Regulation of DNA Translocation Efficiency within the Chromatin Remodeler RSC/Sth1 Potentiates Nucleosome Sliding and Ejection.

Molecules and Cells, 2016
Cedric R. Clapier, M. Kasten, T. Parnell, Ramya Viswanathan, H. Szerlong, G. Sirinakis, Yongli Zhang, B. Cairns   +7 more
semanticscholar   +1 more source

Small Extracellular Vesicles‐Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer

Advanced Science, EarlyView.
sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang, Xueyan Zang, Dongli Wang, Rong Li, Hui Qian, Wenrong Xu, Jiajia Jiang, Yongmin Yan   +7 more
wiley   +1 more source