Results 81 to 90 of about 539,283 (308)
Chromatin-remodeling links metabolic signaling to gene expression
Molecular Metabolism, 2020 Background: ATP-dependent chromatin remodelers are evolutionarily conserved complexes that alter nucleosome positioning to influence many DNA-templated processes, such as replication, repair, and transcription.
Ashby J. Morrison
doaj +1 more source
Genome-wide chromatin remodeling identified at GC-rich long nucleosome-free regions. [PDF]
PLoS ONE, 2012 To gain deeper insights into principles of cell biology, it is essential to understand how cells reorganize their genomes by chromatin remodeling. We analyzed chromatin remodeling on next generation sequencing data from resting and activated T cells to ...
Karin Schwarzbauer +2 more
doaj +1 more source
Chromatin remodeling protein HELLS is critical for retinoblastoma tumor initiation and progression. [PDF]
, 2020 Retinoblastoma is an aggressive childhood cancer of the developing retina that initiates by biallelic RB1 gene inactivation. Tumor progression in retinoblastoma is driven by epigenetics, as retinoblastoma genomes are stable, but the mechanism(s) that ...
Benavente, Claudia A +8 more
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
RNA inhibits dMi-2/CHD4 chromatin binding and nucleosome remodelling [PDF]
, 2021 Ikram Ullah +13 more
openalex +1 more source
The Mechanism of Chromatin Remodeler SMARCAD1/Fun30 in Response to DNA Damage
Frontiers in Cell and Developmental Biology, 2020 DNA packs into highly condensed chromatin to organize the genome in eukaryotes but occludes many regulatory DNA elements. Access to DNA within nucleosomes is therefore required for a variety of biological processes in cells including transcription ...
Ze-Bin Tong +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado +4 more
wiley +1 more source
ATP-dependent chromatin remodeling in the DNA-damage response
Epigenetics & Chromatin, 2012 The integrity of DNA is continuously challenged by metabolism-derived and environmental genotoxic agents that cause a variety of DNA lesions, including base alterations and breaks.
Lans Hannes +2 more
doaj +1 more source
Adr1 and Cat8 mediate coactivator recruitment and chromatin remodeling at glucose-regulated genes. [PDF]
PLoS ONE, 2008 Adr1 and Cat8 co-regulate numerous glucose-repressed genes in S. cerevisiae, presenting a unique opportunity to explore their individual roles in coactivator recruitment, chromatin remodeling, and transcription.We determined the individual contributions ...
Rhiannon K Biddick +2 more
doaj +1 more source
Common CHD8 Genomic Targets Contrast With Model-Specific Transcriptional Impacts of CHD8 Haploinsufficiency. [PDF]
, 2018 The packaging of DNA into chromatin determines the transcriptional potential of cells and is central to eukaryotic gene regulation. Case sequencing studies have revealed mutations to proteins that regulate chromatin state, known as chromatin remodeling ...
Catta-Preta, Rinaldo +3 more
core +6 more sources