Results 11 to 20 of about 182,469 (300)
Basis of specificity for a conserved and promiscuous chromatin remodeling protein. [PDF]
Elife, 2021 Eukaryotic genomes are organized dynamically through the repositioning of nucleosomes. Isw2 is an enzyme that has been previously defined as a genome-wide, nonspecific nucleosome spacing factor. Here, we show that Isw2 instead acts as an obligately targeted nucleosome remodeler in vivo through physical interactions with sequence ...
Donovan DA +8 more
europepmc +4 more sources
Exploring the role of SWI/SNF complex subunit BAF60c in lipid metabolism and inflammation in fish
iScience, 2023 Summary: Chromatin remodeling plays an important role in regulating gene transcription, in which chromatin remodeling complex is a crucial aspect. Brg1/Brm-associated factor 60c (BAF60c) subunit forms a bridge between chromatin remodeling complexes and ...
Jie Sun +7 more
doaj +1 more source
BRG1 HSA domain interactions with BCL7 proteins are critical for remodeling and gene expression
Life Science Alliance, 2023 Interactions between the BRG1 HSA domain and the B-cell CLL/lymphoma 7 proteins facilitate BRG1-mediated chromatin remodeling and induce changes in the gene expression of essential biological pathways.
Nicholas Dietrich +3 more
doaj +1 more source
ATP-dependent chromatin remodeling by Cockayne syndrome protein B and NAP1-like histone chaperones is required for efficient transcription-coupled DNA repair. [PDF]
PLoS Genetics, 2013 The Cockayne syndrome complementation group B (CSB) protein is essential for transcription-coupled DNA repair, and mutations in CSB are associated with Cockayne syndrome--a devastating disease with complex clinical features, including the appearance of ...
Iltaeg Cho +4 more
doaj +1 more source
Tau Stabilizes Chromatin Compaction
Frontiers in Cell and Developmental Biology, 2021 An extensive body of literature suggested a possible role of the microtubule-associated protein Tau in chromatin functions and/or organization in neuronal, non-neuronal, and cancer cells. How Tau functions in these processes remains elusive.
Thomas Rico +11 more
doaj +1 more source
Prothymosin α is a chromatin-remodelling protein in mammalian cells [PDF]
Biochemical Journal, 1998 Prothymosin α (ProTα) is an abundant mammalian acidic nuclear protein whose expression is related to cell proliferation. Here we report that in HL-60 cells overexpressing ProTα, the accessibility of micrococcal nuclease to chromatin is strongly increased. In the DNA ladder generated by the nuclease activity, the sizes of the mononucleosome (146 bp, the
J, Gomez-Marquez, P, Rodríguez
openaire +2 more sources
Interplay between chromatin remodelers and protein arginine methyltransferases [PDF]
Journal of Cellular Physiology, 2007 AbstractChromatin modifying enzymes have emerged as key regulators of all DNA based processes, which control cell growth, development, and differentiation. Recently, it has become clear that different chromatin remodeling and histone‐modifying activities are involved in transcriptional activation and repression. Among the enzymes involved in regulating
Sharmistha, Pal, Saïd, Sif
openaire +2 more sources
Snf2-family proteins: chromatin remodellers for any occasion [PDF]
Current Opinion in Chemical Biology, 2011 Chromatin facilitates the housing of eukaryotic DNA within the nucleus and restricts access to the underlying sequences. Thus, the regulation of chromatin structure provides an excellent platform for regulating processes that require information stored within genomic DNA.
Ryan, Daniel, Owen-Hughes, Tom
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Engineered Chromatin Remodeling Proteins for Precise Nucleosome Positioning [PDF]
Cell Reports, 2019 Regulation of chromatin structure is essential for controlling access of DNA to factors that require association with specific DNA sequences. Here we describe the development and validation of engineered chromatin remodeling proteins (E-ChRPs) for inducing programmable changes in nucleosome positioning by design.
Drake A. Donovan +7 more
openaire +3 more sources
Scientific Reports, 2022 SARS-CoV-2 infection triggers profound and variable immune responses in human hosts. Chromatin remodeling has been observed in individuals severely ill or convalescing with COVID-19, but chromatin remodeling early in disease prior to anti-spike protein ...
Nicholas S. Giroux +23 more
doaj +1 more source