Results 91 to 100 of about 21,822,555 (337)

Biochemical characterization of the placeholder nucleosome for DNA hypomethylation maintenance

Biochemistry and Biophysics Reports, 2019
DNA methylation functions as a prominent epigenetic mark, and its patterns are transmitted to the genomes of offspring. The nucleosome containing the histone H2A.Z variant and histone H3K4 mono-methylation acts as a “placeholder” nucleosome for DNA ...
Rina Hirano, Tomoya Kujirai, Lumi Negishi, Hitoshi Kurumizaka   +3 more
doaj   +1 more source

Nucleosome-Chd1 structure and implications for chromatin remodelling

Nature, 2017
Chromatin-remodelling factors change nucleosome positioning and facilitate DNA transcription, replication, and repair. The conserved remodelling factor chromodomain-helicase-DNA binding protein 1(Chd1) can shift nucleosomes and induce regular nucleosome ...
L. Farnung, S. Vos, C. Wigge, P. Cramer
semanticscholar   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Chromatin state analysis of the barley epigenome reveals a higher-order structure defined by H3K27me1 and H3K27me3 abundance [PDF]

, 2015
This work was supported by grant BBSRC BB/I1022899/1 ‘The diversity and evolution of the gene component of the barley pericentromeric heterochromatin’.Combinations of histones carrying different covalent modifications are a major component of epigenetic ...
Dhillon, Taniya, Milne, Iain, Katie Baker, Baker, Katie, Colas, Isabelle, Taniya Dhillon, Micha Bayer, Bayer, Micha, Milne, Linda, Linda Milne, Flavell, Andrew J., Iain Milne, Andrew J. Flavell, Cook, Nicola, Nicola Cook, Isabelle Colas   +15 more
core   +1 more source

Inferential modeling of 3D chromatin structure

Nucleic Acids Research, 2015
For eukaryotic cells, the biological processes involving regulatory DNA elements play an important role in cell cycle. Understanding 3D spatial arrangements of chromosomes and revealing long-range chromatin interactions are critical to decipher these ...
Siyu Wang, Jinbo Xu, Jianyang Zeng
semanticscholar   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Histone crosstalk directed by H2B ubiquitination is required for chromatin boundary integrity [PDF]

, 2011
Genomic maps of chromatin modifications have provided evidence for the partitioning of genomes into domains of distinct chromatin states, which assist coordinated gene regulation.
West, A., Ma, M.K-W., Adam G West, Heath, C., Carol Heath, Adam G. West, Meiji Kit-Wan Ma, Hair, A., Alan Hair   +8 more
core   +2 more sources

HiCoP, a simple and robust method for detecting interactions of regulatory regions

Epigenetics & Chromatin, 2020
Background Chromatin physical interactions provide essential information for understanding the regulation of cis-elements like enhancers, promoters, and insulators in cell development and differentiation. The Hi-C assay is a technique detecting chromatin
Yan Zhang, Zhaoqiang Li, Shasha Bian, Hao Zhao, Delong Feng, Yanhong Chen, Yuhe Hou, Qifa Liu, Bingtao Hao   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Structure of Histone-based Chromatin in Archaea

Science, 2017
Origin of DNA compaction As a repeating unit in eukaryotic chromatin, a nucleosome wraps DNA in superhelical turns around a histone octamer. Mattiroli et al.
Francesca Mattiroli, S. Bhattacharyya, P. Dyer, Alison E. White, K. Sandman, Brett W. Burkhart, Kyle R Byrne, Thomas Lee, N. Ahn, T. Santangelo, J. Reeve, K. Luger   +11 more
semanticscholar   +1 more source