Results 151 to 160 of about 21,822,555 (337)

Mechanism of chromatin reassembly at the yeast PHO5 promoter upon repression [PDF]

, 2007
The goal of this study has been to elucidate the mechanisms responsible for rebuilding nucleosomes at the PHO5 promoter upon rerepression. In this work, I could unambiguously show that histones are incorporated at the PHO5 promoter upon repression ...
Schermer, Ulrike
core   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

Cell-free system for assembly of transcriptionally repressed chromatin from Drosophila Embryos [PDF]

, 1992
We descrtbe a cell·free system, derlved (rom preblastoderm DrosophÜIJ embryos. ror tbe efficient assembly of eloned DNA into chromatin. Tbe cbromatin assembly system ulilizes cndogcDous eure histones aod assembly racton aod yields loog arrays of ...
Earl Wu, Becker, Peter B., Wu, Chun-Guey, Peter B. Beckert   +3 more
core  

Reconstructing epigenomic dynamics through a single-cell multi-epigenome data integration framework

Nature Communications
Transcriptional regulation arises from the dynamic and combinatorial actions of multiple regulatory factors on genomic DNA. Although many epigenomic regulators have been identified, the precise order in which these factors accumulate at individual gene ...
Takeru Fujii, Kosuke Tomimatsu, Michiko Kato, Miho Ito, Shoko Sato, Hitoshi Kurumizaka, Yuko Sato, Kazumitsu Maehara, Hiroshi Kimura, Akihito Harada, Yasuyuki Ohkawa   +10 more
doaj   +1 more source

Yeast chromatin structure [PDF]

FEBS Letters, 1976
Thomas, Jean O., Furber, Valerie
openaire   +2 more sources

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

Advanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park, Su Yong Kim, MinSu Jeong, Beom Joon Kim, Shin Hyuk Kang, Won‐Gun Koh   +5 more
wiley   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Nuclear Pore Mechanotransduction in Oncology: A Structural Axis of Vulnerability for Targeted Intervention

Advanced Materials, EarlyView.
Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Yun Qian, Wei‐En Yuan, Victor Shahin   +5 more
wiley   +1 more source

Chromatin Structure of the Human NK Cells Perforin Gene Promoter

, 2005
Innate immunity plays a vital role in host defense against viral infection and tumor development. Natural Killer (NK)cells are important for the earliest stage of immuneresponse, which occurs without prior sensitization. NK cells have the ability to kill
CASERTA M., VERDONE L., DI MAURO E., VENDITTI S.   +3 more
core  

DIS3 mutations enhance AID-driven translocations during B-cell activation, promoting transformation to multiple myeloma

Nature Communications
DIS3, a key nuclear RNA-degrading enzyme, is essential for immunoglobulin class switch recombination (CSR), promoting activation-induced cytidine deaminase (AID) activity on both DNA strands to induce double-strand DNA breaks.
Tomasz M. Kuliński, Olga Gewartowska, Mélanie Mahé, Karolina Kasztelan, Nina Durys, Anna Stroynowska-Czerwińska, Marta Jedynak-Slyvka, Ewelina P. Owczarek, Debadeep Chaudhury, Marcin Nowotny, Aleksandra Pękowska, Bertrand Séraphin, Andrzej Dziembowski   +12 more
doaj   +1 more source