Results 141 to 150 of about 253,651 (260)

A heat stress-responsive epigenome defines the dynamic 3D chromatin structure in Chinese cabbage. [PDF]

Plant Physiol
Yang Q, Sun X, Liu M, Zhang X, Liang H, Chang X, Feng D, Lu Y, Hong Y, Zhao J, Ma W.   +10 more
europepmc   +1 more source

stMixer for Scalable Mosaic Integration and Label Transfer in Spatial Histology and Multi‐Omics

Advanced Science, EarlyView.
stMixer is an unsupervised framework for scalable integration and label transfer across spatial histology and multi‐slide multi‐omics data with incomplete modality overlap. It combines self‐looped cross‐attention, multimodal metric learning, and graph‐guided cluster voting to align heterogeneous sections, correct batch effects, and propagate ...
Qixing Yang, Yan Wang, Luonan Chen, Chunman Zuo   +3 more
wiley   +1 more source

Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions. [PDF]

Cell
Li H, Dalgleish JLT, Lister G, Maristany MJ, Huertas J, Dopico-Fernandez AM, Hamley JC, Denny N, Bloye G, Zhang W, Hentges L, Doll R, Wei Y, Maresca M, Dimitrova E, Pytowski L, Tunnacliffe EAJ, Kassouf M, Higgs D, de Wit E, Klose RJ, Schermelleh L, Collepardo-Guevara R, Milne TA, Davies JOJ.   +24 more
europepmc   +1 more source

Chromatin structure related to oncogenesis. [PDF]

Cancer Sci, 2023
Matsumoto S, Horikoshi N, Takizawa Y, Kurumizaka H.   +3 more
europepmc   +1 more source

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source

Sex differences in chromatin structure within the dorsal root ganglion. [PDF]

Pain
Iadarola MJ, Sapio MR, Burbelo PD, Burbelo PD.   +3 more
europepmc   +1 more source

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, EarlyView.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

Predicting gene expression changes from chromatin structure modification. [PDF]

NPJ Syst Biol Appl
Senapati S, Irshad IU, Sharma AK, Kumar H, Kumar H.   +4 more
europepmc   +1 more source

Accurately Deciphering Tissue Heterogeneity From Spatial Multi‐Modal and Multi‐Omics With STransformer

Advanced Science, EarlyView.
STransformer is a unified deep learning framework designed to seamlessly accommodate a comprehensive landscape of spatial data. By simultaneously capturing short‐range cellular interactions and tissue‐wide semantic patterns, it extracts robust representations to accurately dissect complex tissue heterogeneity.
Xingyi Li, Jialuo Xu, Gaoyuan Du, Xiangting Jia, Dongmin Zhao, Chunyan Zhou, Kexin Xiao, Jia Gu, Junnan Zhu, Xuequn Shang   +9 more
wiley   +1 more source

TET2 cascade: a novel regulator of chromatin structure and leukaemogenesis. [PDF]

Signal Transduct Target Ther
Dempke WCM, Fenchel K.
europepmc   +1 more source