Results 121 to 130 of about 21,822,555 (337)

Linker histone H1 represses H3 tail acetylation induced by H4 tail acetylation and alters its dynamics

Communications Biology
The nucleosome is the fundamental chromatin unit, containing two copies of histones H2A, H2B, H3, and H4 wrapped by ~ 146 bp of core DNA plus linker DNA; addition of linker histone H1 forms a chromatosome.
Ayako Furukawa, Kenta Echigoya, Samuel Blazquez, Masatoshi Wakamori, Hideaki Ohtomo, Yasuo Tsunaka, Takashi Umehara, Tsuyoshi Terakawa, Yoshimasa Takizawa, Hitoshi Kurumizaka, Yoshifumi Nishimura   +10 more
doaj   +1 more source

Two independent modes of chromatin organization revealed by cohesin removal

Nature, 2017
Imaging and chromosome conformation capture studies have revealed several layers of chromosome organization, including segregation into megabase-sized active and inactive compartments, and partitioning into sub-megabase domains (TADs). It remains unclear,
Wibke Schwarzer, Nezar Abdennur, A. Goloborodko, Aleksandra Pękowska, G. Fudenberg, Yann Loe-Mie, Nuno A. Fonseca, W. Huber, C. Haering, L. Mirny, F. Spitz   +10 more
semanticscholar   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Probing the (H3-H4)(2) histone tetramer structure using pulsed EPR spectroscopy combined with site-directed spin labelling [PDF]

, 2009
The (H3-H4)(2) histone tetramer forms the central core of nucleosomes and, as such, plays a prominent role in assembly, disassembly and positioning of nucleosomes.
Ward, Richard, Owen-Hughes, Tom; id_orcid, Norman, David G., Bowman, Andrew, El-Mkami, Hassane, Bowman, A., Owen-Hughes, Tom   +6 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Changes in large-scale chromatin structure and dynamics of BAC transgenes during transcriptional activation [PDF]

, 2010
Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by William Ingram (wingram2@illinois.edu) on 2010-05-14T20:52:51Z Item is restricted until 2012-05-14T20:52:43ZMounting evidence suggests that the eukaryotic cell nucleus is a dynamic
Hu, Yan
core  

RNA polymerase II promotes the organization of chromatin following DNA replication

EMBO Reports
Understanding how chromatin organisation is duplicated on the two daughter strands is a central question in epigenetics. In mammals, following the passage of the replisome, nucleosomes lose their defined positioning and transcription contributes to their
Susanne Bandau, Vanesa Alvarez, Hao Jiang, Sarah Graff, Ramasubramanian Sundaramoorthy, Marek Gierlinski, Matt Toman, Tom Owen-Hughes, Simone Sidoli, Angus Lamond, Constance Alabert   +10 more
doaj   +1 more source

Chromatin structure [PDF]

Biochemical Journal, 1971
B M, Richards, J F, Pardon, A S, Pooley
openaire   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Studies toward in vitro reconstitution of plant chromatin [PDF]

, 2009
To study the relation between chromatin structure and DNA function in detail it is necessary to have an in vitro procedure for assembling nucleosomes on a naked DNA template with properties similar to native chromatin.
NC DOCKS at Western Carolina University, Martinez, Nicholas   +1 more
core