Results 131 to 140 of about 21,822,555 (337)

H2A.Z facilitates access of active and repressive complexes to chromatin in embryonic stem cell self-renewal and differentiation. [PDF]

, 2013
SummaryChromatin modifications have been implicated in the self-renewal and differentiation of embryonic stem cells (ESCs). However, the function of histone variant H2A.Z in ESCs remains unclear.
Northrup, D., Levens, D., Tang, Q., Liu, Chengyu, Zhao, Keji, Hu, G., Cui, K., Wang, Chaochen, Hu, Gangqing, Crane-Robinson, Colyn, Ge, Kai, Northrup, Daniel, Wang, C., Tang, Qingsong, Zhao, K., Levens, David, Liu, C., Cui, Kairong, Ge, K.   +18 more
core   +1 more source

Conservation and divergence in higher order chromatin structure [PDF]

, 2013
Aspects of higher order chromatin structure such as replication timing, lamina association and Hi-C inter-locus interactions have been recently studied in several human and mouse cell types and it has been suggested that most of these features of ...
Chambers, Emily Victoria
core   +3 more sources

Wapl is an essential regulator of chromatin structure and chromosome segregation

Nature, 2013
Mammalian genomes contain several billion base pairs of DNA that are packaged in chromatin fibres. At selected gene loci, cohesin complexes have been proposed to arrange these fibres into higher-order structures, but how important this function is for ...
A. Tedeschi, G. Wutz, S. Huet, M. Jaritz, Annelie Wuensche, Erika Schirghuber, I. Davidson, Wen Tang, David A. Cisneros, V. Bhaskara, Tomoko Nishiyama, A. Vaziri, A. Wutz, J. Ellenberg, J. Peters   +14 more
semanticscholar   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

BAC transgene arrays as a model system for studying large-scale chromatin structure [PDF]

, 2011
The folding of interphase chromatin into large-scale chromatin structure and its spatial organization within nucleus has been suggested to have important roles in gene regulation.
Bian, Qian
core  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Chromatin Architecture Reorganization during Stem Cell Differentiation

Nature, 2015
Higher-order chromatin structure is emerging as an important regulator of gene expression. Although dynamic chromatin structures have been identified in the genome, the full scope of chromatin dynamics during mammalian development and lineage ...
Jesse R. Dixon, Inkyung Jung, Siddarth Selvaraj, Yin Shen, Jessica E. Antosiewicz-Bourget, A. Lee, Zhen Ye, Audrey Kim, N. Rajagopal, Wei Xie, Yarui Diao, Jing Liang, Huimin Zhao, Victor V Lobanenkov, J. Ecker, J. Thomson, B. Ren   +16 more
semanticscholar   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Nuclear factor I genomic binding associates with chromatin boundaries [PDF]

, 2013
BACKGROUND: The Nuclear Factor I (NFI) family of DNA binding proteins (also called CCAAT box transcription factors or CTF) is involved in both DNA replication and gene expression regulation.
Armelle Gaussin, Schmid, Christoph D., Mermod, Nicolas, Jozef Adamcik, Ambrosini, Giovanna, Schmid, C. D., Pjanic, P., Giovanna Ambrosini, Plasari, Genta, Genta Plasari, Bucher, P., Adamcik, Jozef, Kerschgens, J., Christoph D Schmid, Petar Pjanic, Pjanic, Petar, Kerschgens, Jan, Ambrosini, G., Pjanic, Milos, Gaussin, Armelle, Gaussin, A., Pjanic, M., Philipp Bucher, Plasari, G., Jan Kerschgens, Adamcik, J., Giovani Dietler, Bucher, Philipp, Milos Pjanic, Dietler, Giovani, Dietler, G., Schmid, C.D., Nicolas Mermod, Mermod, N.   +33 more
core   +2 more sources

A Conserved Role for Human Nup98 in Altering Chromatin Structure and Promoting Epigenetic Transcriptional Memory

PLoS Biology, 2013
In yeast and humans, interaction of a nuclear pore protein with promoters alters chromatin structure and allows RNA polymerase II to bind, poising them for faster reactivation for several generations.
W. Light, Jonathan E Freaney, Varun Sood, Abbey C. Thompson, Agustina D’Urso, C. Horvath, Jason H. Brickner   +6 more
semanticscholar   +1 more source