Results 51 to 60 of about 125,999 (289)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Simultaneous determination of several forms of phosphate in food by ion exchange chromatography

Tạp chí Kiểm nghiệm và An toàn thực phẩm
The phosphate group is a group of food additives commonly used for moisturizing, improving the structure, and retaining the color and flavor of products prepared from meat, fish, milk, baked goods, and beverages.
Do Thi Hong Thuy, Nguyen Nhu Thuong, Vu Thi Trang, Le Thi Hong Hao, Le Thi Thuy, Le Viet Ngan, Luu Thi Huyen Trang, Cao Cong Khanh, Dinh Viet Chien, Le Thi Phuong Thao, Nguyen Thi Anh Huong   +10 more
doaj   +1 more source

Formation of dimers in refolding of recombinant human interferon-γ by ion-exchange chromatography

浙江大学学报. 农业与生命科学版, 2006
The refolding process was performed by gradually decreasing the concentration of urea in the buffer after the denatured rhIFN-γ proteins had been bound onto the ion-exchange gel SP Sepharose Fast Flow.
JIN Ting, GUAN Yi-xin, YAO Shan-jing
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Zein‐Based Adhesives: Sustainable Extraction and Application in Bioadhesive Technologies

Advanced Engineering Materials, EarlyView.
Zein is extracted from corn gluten meal using a simple and scalable process with high yield (~90%). The resulting protein is applied in bioadhesives modified with Ca2+ and Fe3+ ions, exhibiting substrate‐dependent adhesion. The findings demonstrate competitive bonding performance and highlight the role of ionic interactions in tuning adhesion ...
Paula Bertolino Sanvezzo, Daniela Winsley Valereto Friozi, Vinícius de Oliveira, Marcia Cristina Branciforti   +3 more
wiley   +1 more source

A method for suppressing pH excursion during elution in ion-exchange chromatography

Journal of Chromatography Open
A simple method for reducing pH excursion during salt-induced elution in cation exchange chromatography is presented in this paper. Connecting a preequilibrated anion exchange cartridge in series in front of the cation exchange device just prior to the ...
Raja Ghosh
doaj   +1 more source

Extraction and Purification of Lactoferrin from Camel Milk and Investigation of Its Amylase Activity

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: Lactoferrin is found in mucus, milk, and colostrum secretions and has antimicrobial activities, improves iron absorption, and enhances immune responses. Lactoferrin has the ability to degrade starch.
Saeed Zibaei, Anis Bakhshani, Ali Bidmeshkipour   +2 more
doaj  

A novel silica based click lysine anion exchanger for ion exchange chromatography

, 2011
A novel silica based click lysine anion exchanger for ion exchange chromatographyIon chromatography (IC) is one of the most powerful analysis technologies for the determination of charged compounds.
Guo, Hongyue, ChanghuChu, Li, Yan, Liang, Xinmiao, Chu, Changhu, BingchengYang, Yang, Bingcheng   +6 more
core   +1 more source

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source