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Chromoanasynthesis

Methods in Molecular Biology
Chromoanasynthesis is a distinct entity within the complex rearrangement phenomena grouped under the name chromoanagenesis. The formation of chromoanasynthesis is linked to defective or interrupted DNA replication, due to various replicative stress factors.
Frédéric Morel, Vincent Gatinois
exaly   +4 more sources

Shattered and stitched chromosomes—chromothripsis and chromoanasynthesis—manifestations of a new chromosome crisis?

Genes Chromosomes and Cancer, 2012
AbstractChromothripsis (chromosome shattering) has been described as complex rearrangements affecting single chromosome(s) in one catastrophic event. The chromosomes would be “shattered” and “stitched together” during this event. This phenomenon is proposed to constitute the basis for complex chromosomal rearrangements seen in 2‐3% of all cancers and ...
Sabine Mai, Christiaan Righolt
exaly   +4 more sources

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Constitutional chromoanasynthesis: description of a rare chromosomal event in a patient

European Journal of Medical Genetics, 2014
Structural alterations in chromosomes are a frequent cause of cancers and congenital diseases. Recently, the phenomenon of chromosome crisis, consisting of a set of tens to hundreds of clustered genomic rearrangements, localized in one or a few chromosomes, was described in cancer cells under the term chromothripsis. Better knowledge and recognition of
Julie Plaisancié, Kleinfinger Pascale
exaly   +3 more sources

Genomic Detection and Delineation of Chromoanasynthesis by Mate-Pair Sequencing

Methods in Molecular Biology
Chromoanagenesis encompasses catastrophic genomic rearrangements, with chromoanasynthesis referring to unbalanced germline events involving one or multiple chromosomes, distinct from the mostly balanced rearrangements seen in cancer-associated chromothripsis and chromoplexy. Initially identified via chromosomal microarray analysis (CMA) and custom high-
Kwong Wai Choy, Zirui Dong, Sau W Cheung   +2 more
exaly   +3 more sources

A Rare Form Of Constitutional Chromoanasynthesis: Ring Chromosome 18

, 2020
Durak Aras, Beyhan, Susam, Ezgi, Tosumoğlu, Efsun, Kocagil, Sinem, Erzurumluoğlu Gökalp, Ebru, Artan, Sevilhan, Çilingir, Oğuz   +6 more
openaire   +2 more sources

Complex X-Chromosomal Rearrangements in Two Women with Ovarian Dysfunction: Implications of Chromothripsis/Chromoanasynthesis-Dependent and -Independent Origins of Complex Genomic Alterations

Cytogenetic and Genome Research, 2016
Our current understanding of the phenotypic consequences and the molecular basis of germline complex chromosomal rearrangements remains fragmentary. Here, we report the clinical and molecular characteristics of 2 women with germline complex X-chromosomal rearrangements.
Erina Suzuki, Hirohito Shima, Machiko Toki, Kunihiko Hanew, Keiko Matsubara, Hiroki Kurahashi, Satoshi Narumi, Tsutomu Ogata, Tsutomu Kamimaki, Maki Fukami   +9 more
openaire   +2 more sources

eP402: Partial trisomy of chromosome 22 mediated by chromoanasynthesis in an 8-month-old male

Genetics in Medicine, 2022
Tam Sneddon, Ashley Pendleton, Arti Pandya, Kathleen Kaiser-Rogers, Lori Ramkissoon   +4 more
openaire   +1 more source

How Chaotic Is Genome Chaos?

Cancers, 2021
James A Shapiro
exaly  

Chromoanasynthesis: another way for the formation of complex chromosomal abnormalities in human reproduction

Human Reproduction, 2018
Franck Pellestor, Vincent Gatinois
exaly  

Detection of complex genomic signatures associated with risk in plasma cell disorders

Cancer Genetics, 2017
Rodney Scott, Anoop Enjeti, Philip Rowlings   +2 more
exaly