Results 51 to 60 of about 946 (139)

The tandem duplicator phenotype as a distinct genomic configuration in cancer

Proceedings of the National Academy of Sciences of the United States of America, 2016
Next-generation sequencing studies have revealed genome-wide structural variation patterns in cancer, such as chromothripsis and chromoplexy, that do not engage a single discernable driver mutation, and whose clinical relevance is unclear.
F. Menghi, K. Inaki, X. Woo, Pooja Kumar, K. Grzeda, A. Malhotra, Vinod Yadav, Hyunsoo Kim, E. Márquez, D. Ucar, P. Shreckengast, Joel Wagner, George MacIntyre, Krishna R. Murthy Karuturi, R. Scully, J. Keck, Jeffrey H. Chuang, E. Liu   +17 more
semanticscholar   +2 more sources

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +2 more sources

Pitfalls and missing links in current understanding of 4D genomes

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract The spatial and temporal organization of the genome—collectively termed the 4D genome—is pivotal for regulating gene expression, maintaining genome stability, and guiding development. The convergence of chromosome conformation capture technologies, super‐resolution microscopy, and single‐cell epigenomics has transformed our understanding of ...
Michael Q. Zhang
wiley   +1 more source

Recurrent SPECC1L–NTRK fusions in pediatric sarcoma and brain tumors [PDF]

, 2020
The identification of rearrangements driving expression of neurotrophic receptor tyrosine kinase (NTRK) family kinases in tumors has become critically important because of the availability of effective, specific inhibitor drugs.
Nagabushan, S, Hansford, JR, Kumar, A, Gifford, AJ, Brown, L.M., Ziegler, D.S., Wong-Erasmus, Marie, Fox, S.B., Kumar, A., Mayoh, C, Haber, M, Ludlow, L.E., Khuong-Quang, D.-A., Desai, J, Ekert, P.G., Marshall, GM, Khuong-Quang, DA, Sexton-Oates, A., Rodriguez, M, Sexton-Oates, A, Cowley, M.J., Desai, J., Cowley, MJ ; https://orcid.org/, Haber, M., Lau, L, Nagabushan, S., Rodriguez, M., Ekert, PG, Wong, M., Gifford, A.J., Pinese, M., Mayoh, C., Wong, M, Cowley, MJ, Ludlow, LE, Lau, L., Brown, LM, Marshall, G.M., Hansford, J.R., Pinese, M, Fox, SB, Ziegler, DS, Haber, M ; https://orcid.org/   +42 more
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A molecular cytogenetic perspective on chromosome biology and crop improvement

The Plant Genome, Volume 18, Issue 4, December 2025.
Abstract The age of molecular cytogenetic analysis of crop plants dawned in the late 1960s and early 1970s with new advances in the identification of somatic chromosomes by C‐banding and fluorescence in situ hybridization concurrent with advances in DNA cloning, sequencing, and mapping. In this perspective article dedicated to Ronald Phillips, I review
Bikram S. Gill
wiley   +1 more source

Chromosome Changes in Soma and Germ Line: Heritability and Evolutionary Outcome

, 2022
The origin and inheritance of chromosome changes provide the essential foundation for natural selection and evolution. The evolutionary fate of chromosome changes depends on the place and time of their emergence and is controlled by checkpoints in ...
Irina Bakloushinskaya
core   +1 more source

Unraveling Ewing Sarcoma Tumorigenesis Originating from Patient-Derived Mesenchymal Stem Cells

, 2021
Ewing sarcoma is characterized by pathognomonic translocations, most frequently fusing EWSR1 with FLI1. An estimated 30% of Ewing sarcoma tumors also display genetic alterations in STAG2, TP53, or CDKN2A (SPC). Numerous attempts to develop relevant Ewing
Brunet, Erika; https://orcid.org/, Kaltenbach, Sophie, Brunet, Erika, Grünewald, Thomas G P, Zaïdi, Sakina, Jasin, Maria, Couronné, Lucile, Sole, Anna, Janoueix-Lerosey, Isabelle, Heintzé, Maxime, Pierre-Eugène, Cécile, Couronné, Lucile; https://orcid.org/, Revy, Patrick, De Cian, Anne, Giovannangeli, Carine, Grossetête, Sandrine, Renouf, Benjamin, Grünewald, Thomas G.P., Surdez, Didier, Delattre, Olivier, Babin, Loelia, Surdez, Didier; https://orcid.org/, Tomishima, Mark, Revy, Patrick; https://orcid.org/   +23 more
core   +1 more source

Genome Instability in Multiple Myeloma: Facts and Factors [PDF]

, 2021
Multiple myeloma (MM) is a malignant neoplasm of terminally differentiated immunoglobulin-producing B lymphocytes called plasma cells. MM is the second most common hematologic malignancy, and it poses a heavy economic and social burden because it remains
Youri I. Pavlov, Zhuk, Anna, Aksenova, Anna, Irina V. Zotova, Zotova, Irina, Anna Y. Aksenova, Artem G. Lada, Elena I. Stepchenkova, Pavlov, Youri, Stepchenkova, Elena, Kostroma, Ivan, Ivan I. Kostroma, Lada, Artem, Gritsaev, Sergey, Anna S. Zhuk, Sergey V. Gritsaev   +15 more
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Integration of Optical Genome Mapping in the Cytogenomic and Molecular Work‐Up of Hematological Malignancies: Expert Recommendations From the International Consortium for Optical Genome Mapping

American Journal of Hematology, Volume 100, Issue 6, Page 1029-1048, June 2025.
ABSTRACT The latest updates to the classification of hematolymphoid malignancies using the World Health Organization (WHO, 5th ed.) and ICC (International Consensus Classification) criteria highlight the critical need for comprehensive and precise cytogenomic data for diagnosis, prognostication, and treatment.
Rashmi Kanagal‐Shamanna, Anna Puiggros, Isabel Granada, Gordana Raca, Katrina Rack, Mar Mallo, Barbara Dewaele, Adam C. Smith, Yassmine Akkari, Brynn Levy, Robert P. Hasserjian, Adela Cisneros, Marta Salido, Guillermo Garcia‐Manero, Hui Yang, M. Anwar Iqbal, Ravindra Kolhe, Francesc Solé, Blanca Espinet   +18 more
wiley   +1 more source

Table_1_Linked-read based analysis of the medulloblastoma genome.xlsx

, 2023
IntroductionMedulloblastoma is the most common type of malignant pediatric brain tumor with group 4 medulloblastomas (G4 MBs) accounting for 40% of cases. However, the molecular mechanisms that underlie this subgroup are still poorly understood.
Melissa Zwaig (15217754), Nada Jabado (4544824), Michael D. Taylor (6879950), Marco Gallo (226844), John J.Y. Lee (16701966), Hamza Farooq (3953483), Jiannis Ragoussis (16749), Michael J. Johnston (630595)   +7 more
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