Results 61 to 70 of about 946 (139)

UESL display structural genomic instability.

, 2020
A, Overview of genome wide copy number variation (CNV) in UESL tumors derived from high density SNP arrays. The majority of UESL (top) display frequent CNV indicative of aneuoploidy. A minority of tumors (bottom) displays quiet genomes.
Ling Cen (79141), Fredrik Pettersson (21630), Andrew S. Brohl (7423418), Damon R. Reed (7423421), Chia-Ho Cheng (108443), Elsa R. Flores (8735748), Bhuvana A. Setty (8735739), Michael Arnold (3311568), Goodwin G. Jinesh (5870897), Sean J. Yoder (8735742), Jamie K. Teer (8735745)   +10 more
core   +1 more source

Structural Variant Analysis of Complex Karyotype Myelodysplastic Neoplasia Through Optical Genome Mapping

Genes, Chromosomes and Cancer, Volume 64, Issue 1, January 2025.
ABSTRACT Myelodysplastic neoplasia with complex karyotype (CK‐MDS) poses significant clinical challenges and is associated with poor survival. Detection of structural variants (SVs) is crucial for diagnosis, prognostication, and treatment decision‐making in MDS.
Andriana Valkama, Sandra Vorimo, Anna Tervasmäki, Hannele Räsänen, Eeva‐Riitta Savolainen, Katri Pylkäs, Tuomo Mantere   +6 more
wiley   +1 more source

Chromosome aberrations cause tumorigenesis through chromosomal rearrangements in a hepatocarcinogenesis rat model

Cancer Science, Volume 115, Issue 11, Page 3612-3621, November 2024.
The pure chromosome aberration‐inducer acetamide caused hepatocarcinogenesis in a rat model through chromosomal rearrangements characterized by copy number alterations and structural alterations. The chromosomal rearrangements induced some specific oncogene amplifications in hepatic tumors.
Kenji Nakamura, Yuji Ishii, Shinji Takasu, Moeka Namiki, Meili Soma, Norifumi Takimoto, Kohei Matsushita, Makoto Shibutani, Kumiko Ogawa   +8 more
wiley   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +2 more sources

DataSheet_1_Linked-read based analysis of the medulloblastoma genome.pdf

, 2023
IntroductionMedulloblastoma is the most common type of malignant pediatric brain tumor with group 4 medulloblastomas (G4 MBs) accounting for 40% of cases. However, the molecular mechanisms that underlie this subgroup are still poorly understood.
Melissa Zwaig (15217754), Nada Jabado (4544824), Michael D. Taylor (6879950), Marco Gallo (226844), John J.Y. Lee (16701966), Hamza Farooq (3953483), Jiannis Ragoussis (16749), Michael J. Johnston (630595)   +7 more
core   +1 more source

Malignant melanoma in a 12‐year‐old boy 17 months after completing hepatoblastoma treatment

Cancer Reports, Volume 7, Issue 5, May 2024.
Abstract Background Melanoma is rare as a secondary malignant neoplasm among childhood cancer survivors. Case We report a case of a 12‐year‐old boy who developed malignant melanoma with systemic metastases 17 months after completing treatment for hepatoblastoma. The diagnosis was made unexpectedly based on a bone marrow examination. The patient did not
Koji Kanezawa, Hiroshi Yagasaki, Ayumu Arakawa, Reina Hoshi, Shuichiro Uehara, Ichiro Morioka   +5 more
wiley   +1 more source

Hybrid sequencing resolves two germline ultra-complex chromosomal rearrangements consisting of 137 breakpoint junctions in a single carrier

, 2021
Chromoanagenesis is a genomic event responsible for the formation of complex structural chromosomal rearrangements (CCRs). Germline chromoanagenesis is rare and the majority of reported cases are associated with an affected phenotype.
Eisfeldt, Jesper,, Nilsson, Daniel,, Nilsson, Daniel, Pettersson, Maria,, Petri, Anna, Eisfeldt, Jesper, Feuk, Lars, Pettersson, Maria, Lindstrand, Anna,, Feuk, Lars,, Lindstrand, Anna, Petri, Anna,   +11 more
core   +1 more source

Neoantigenic potential of complex chromosomal rearrangements in mesothelioma

Journal of Thoracic Oncology, 2018
Introduction: Malignant pleural mesothelioma is a disease primarily associated with exposure to the carcinogen asbestos. Whereas other carcinogen‐related tumors are associated with a high tumor mutation burden, mesothelioma is not.
A. Mansfield, T. Peikert, J. Smadbeck, J. Udell, E. Garcia-Rivera, Laura R. Elsbernd, C. Erskine, V. V. Van Keulen, F. Kosari, S. Murphy, Hongzheng Ren, Vishnu Serla, Janet L. Schaefer Klein, Giannoula Karagouga, F. Harris, Carlos P. Sosa, Sarah Johnson, W. Nevala, S. Markovic, A. Bungum, E. Edell, Haidong Dong, J. Cheville, M. Aubry, J. Jen, G. Vasmatzis   +25 more
semanticscholar   +1 more source

Quantitative and qualitative mutational impact of ionizing radiation on normal cells

, 2022
<p><strong>Summary of the research</strong></p> <p>The comprehensive genomic impact of ionizing radiation (IR), a carcinogen, on healthy somatic cells remains unclear.
Shin, Jong-Yeon, Ju, Young Seok, Park, Seongyeol, Jeon, Sara, Kim, HyoJin, Bae, Min Ji, Yi, On Vox, Kwon, Hyun Woo, Lee, Eon-Seok, Son, Tae Gen, Chang, Ji Hyun, Kim, Ryul, Yu, Tosol, Cho, Youngwon, An, Yohan, Choi, Jinwook, Lee, Hyunsook, Kim, Taewoo, Kim, Su Yeon, Min, Dong-Wook, Kim, Kyung Su, Lee, Dong Soo, Lee, Chang Geun, Kim, Tae You, Lee, Joo-Hyeon, Kang, Yeong-Rok, Yi, Kijong, Kim, Joon-Goon, Koo, Bon-Kyoung, Lim, Joonoh, Nam, Chang Hyun, Choi, Si Ho, Han, Eon Chul, Na, Hyelin, Ku, Taeyun, Youk, Jeonghwan, Kim, Eunji, Kim, Young Seo, Lee, Won-Chul   +38 more
core   +1 more source

Long-read Oxford Nanopore sequencing reveals complex rearrangements and regulatory disruption in malignant pleural mesothelioma

medRxiv
Malignant pleural mesothelioma (MPM) is a rare malignancy characterised by extensive structural genomic alterations and a low burden of recurrent single nucleotide variants.
M. Alhazmi, C. Poile, J. Dzialo, A. Bzura, K. Kutywayo, D. Fennell, E. Hollox   +6 more
semanticscholar   +1 more source