Results 131 to 140 of about 93,154 (303)

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

Chromosomal instability is associated with prognosis and efficacy of bevacizumab after resection of colorectal cancer liver metastasis

Annals of Medicine
Introduction Individualized treatment of colorectal cancer liver metastases (CRLM) remains challenging due to differences in the severity of metastatic disease and tumour biology. Exploring specific prognostic risk subgroups is urgently needed.
Weihao Li, Jin Lan, Chi Zhou, Rong Yang, Jiayu Wang, Jiahua He, Binyi Xiao, Qingjian Ou, Yujing Fang, Wenhua Fan, Junzhong Lin, Zhizhong Pan, Jianhong Peng, Xiaojun Wu   +13 more
doaj   +1 more source

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

Mouse Models for Chromosomal Instability

, 2012
Cancer is the result of several genetic alterations that overrule a cell’s protection mechanisms against unscheduled proliferation (Hanahan & Weinberg, 2000). As the vast majority of human tumours show chromosomal instability (CIN), CIN is believed to be an important driver and facilitator of oncogenic transformation.
openaire   +3 more sources

Chromosomal instability drives metastasis through a cytosolic DNA response

, 2020
Chromosomal instability is a hallmark of cancer that results from ongoing errors in chromosome segregation during mitosis. Although chromosomal instability is a major driver of tumour evolution, its role in metastasis has not been established.
Lewis C Cantley (8990546), Vinagolu K Rajasekhar (8990519), Neil K Taunk (8990513), Christine Shaw (7653917), Julie-Ann Cavallo (8990501), Olivier Elemento (7617), Mercedes Duran (5651374), Nancy Y Lee (8990534), Roshan K Sriram (8990507), John H Healey (8990528), Kalyani Chadalavada (8990516), Gouri Nanjangud (8769289), Marcin Imielenski (8990537), Jan Lammerding (742680), Nicholas McGranahan (594459), Charles J Murphy (8990504), Christine H Chung (8990531), Thomas BK Watkins (8990510), Simon N Powell (8990543), Giulio Genovese (120795), Quincey LaPlant (7539809), Bryan Ngo (8990495), Peter Ly (3327750), Nicolai J Birkbak (8990522), Don W Cleveland (8990540), Subramanian Venkatesan (791899), Ashley M Laughney (8990498), Pragya Shah (4051345), Charles Swanton (236153), Dana Pe'er (267534), Chantal Pauli (3705442), Mark Lundquist (8990525), Samuel F Bakhoum (8990492)   +32 more
core  

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source

Impact of chromosomal instability on colorectal cancer progression and outcome

, 2014
International audienceBACKGROUND: It remains presently unclear whether disease progression in colorectal carcinoma (CRC), from early, to invasive and metastatic forms, is associated to a gradual increase in genetic instability and to a scheme of ...
Bascoul-Mollevi, Caroline, Béatrice Orsetti, Gordien, Karine, Janick Selves, Rosine Guimbaud, Massemin, Blandine, François Paraf, Charles Theillet, Bibeau, Frédéric, Cazaux, Christophe, Valérie Dapremont, Hostein, Isabelle, Christophe Cazaux, Theillet, Charles, Blandine Massemin, Orsetti, Béatrice, Caroline Bascoul-Mollevi, Michel Longy, Dapremont, Valérie, Selves, Janick, Paraf, François, Karine Gordien, Isabelle Hostein, Isabelle Soubeyran, Frédéric Bibeau, Guimbaud, Rosine, Soubeyran, Isabelle, Longy, Michel, Laurence Lasorsa, Lasorsa, Laurence   +29 more
core   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Chromosomal Instability at Common Fragile Sites in Seckel Syndrome

, 2004
Seckel syndrome (SCKL) is a rare, genetically heterogeneous disorder, with dysmorphic facial appearance, growth retardation, microcephaly, mental retardation, variable chromosomal instability, and hematological disorders.
Arlt, Martin F., Casper, Anne M., Durkin, Sandra G., Glover, Thomas W.   +3 more
core   +1 more source

Differential Prognostic Impact of Prior Cholecystectomy Between Proximal and Distal Colorectal Cancer: A 12‐Year Retrospective Cohort Study of 3487 Consecutive Patients

Annals of Gastroenterological Surgery, EarlyView.
In this retrospective cohort of 3487 patients with CRC, history of CCY was associated with significantly worse prognosis in patients with proximal CRC but not in those with distal CRC. This differential prognostic impact showed a statistically significant interaction between tumor location and history of CCY and remained robust after PSM.
Masashi Tsunematsu, Koichiro Haruki, Kazuhiro Yanamoto, Takuo Takehana, Shunta Ishizaki, Mitsuru Yanagaki, Yoshihiro Shirai, Kenei Furukawa, Shinji Onda, Toru Ikegami   +9 more
wiley   +1 more source