Results 121 to 130 of about 93,154 (303)

Liability to Chromosome Damage in Lymphocytes of “Cancer Family” Subjects: A Study of Spontaneous and Induced Chromosomal Fragility

The International Journal of Biological Markers, 1987
Spontaneous chromosomal fragility was detected in seven tumor patients and one healthy member from two families with a high recurrence of cancer. Major chromosome lesions, such as terminal deletions and rearranged chromosomes, were found at levels ...
Lidia Larizza, Luisa Doneda, Miria Stefanini, Giuseppa Francone, Valter Gualandri, Annamaria Fuhrman Conti   +5 more
doaj   +1 more source

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source

Chromosomal instability and human cancer [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2005
Abstract Genetic instability is a defining feature of human cancer. The main type of genetic instability, chromosomal instability (CIN), enhances the rate of gross chromosomal changes during cell division. CIN is brought about by mutations of CIN genes, i.e. genes that are involved in maintaining the genomic integrity of the cell.
openaire   +2 more sources

Mutations in the APC tumour suppressor gene cause chromosomal instability

, 2001
Two forms of genetic instability have been described in colorectal cancer1: microsatellite instability and chromosomal instability. Microsatellite instability results from mutations in mismatch repair genes; chromosomal instability is the hallmark of ...
Fodde, Riccardo, Giles, Rachel H., Riccardo Fodde, Johan H. van Es, Cor Breukel, Clevers, Hans, Ron Smits, Kuipers, Jeroen, Joop Wiegant, Wiegant, Joop, Jeroen Kuipers, Carla Rosenberg, Hans Clevers, Menno Kielman, Gaspar, Claudia, Smits, Ron, Rosenberg, Carla, Rachel H. Giles, Kielman, Menno, Van Es, Johan H., Claudia Gaspar, Breukel, Cor, Fodde, Riccardo; id_orcid   +22 more
core   +1 more source

Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes

Advanced Science, EarlyView.
PSTT cells, through cell fusion with B cells, incorporate abundant non‐inherited maternal genes that are detectable by DNIMA. These hybrid cells acquire immunotherapy‐resistant genetic changes and increase the expression of B cell‐derived immune‐related molecules such as Ig, HLA, LILRB, SIGLEC10, and so on, creating an immunotolerant environment around
Kyosuke Kagami, Masanori Ono, Yasunari Mizumoto, Tatsuhito Kanda, Takashi Iizuka, Takiko Daikoku, Shin‐ichi Horike, Akira Hattori, Akihito Horie, Sachiko Minamiguchi, Tomoko Fujiwara, Kazuyoshi Hosomichi, Atsushi Tajima, Hirokazu Usui, Kaoru Abiko, Hiroshi Fujiwara   +15 more
wiley   +1 more source

The Two Faces of Saccharomyces cerevisiae RAD9 Function in Homologous Recombination: Suppressor and Promoter of Genome Instability

DNA
Recombinogenic DNA damage can initiate chromosomal rearrangements that can alter gene expression or accelerate cancer progression in higher eukaryotes.
Michael Fasullo
doaj   +1 more source

Molecular characterisation of chromosomal instability in scleroderma [PDF]

, 1996
Scleroderma is not considered to be a disorder of chromosomal instability, but previous cytogenetic analyses have reported a wide range of chromosomal abnormalities in these patients and family members.
Artlett, Carolyn May
core  

Colorectal cancers with microsatellite instability display mRNA expression signatures characteristic of increased immunogenicity

, 2004
Background Colorectal cancers displaying high-degree microsatellite instability (MSI-H) have an improved prognosis compared to microsatellite stable (MSS) cancers.
Huang Fei, Bustin, SA, Shaw Peter M, Roger Feakins, Hands Rebecca E, Banerjea, A, Fei Huang, Stephen A Bustin, Bustin Stephen A, Han Xia, Dorudi, S, Shafi Ahmed, Ayan Banerjea, Hands, RE, Ahmed, S, Feakins, R, Han, X, Feakins Roger, Sina Dorudi, Shaw, PM, Peter M Shaw, Banerjea Ayan, Xia Han, Huang, F, Rebecca E Hands, Dorudi Sina, Ahmed Shafi   +26 more
core   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

Chromosomal Instability: Mad2 beyond the Spindle Checkpoint

, 2012
SummaryWhat specific defects can cause chromosomal instability in cancer cells? Overexpression of the mitotic checkpoint protein Mad2 triggers chromosome missegregation but, surprisingly, Mad2 exerts this effect through a previously unknown effect on ...
Lampson, Michael A., Ballister, Edward R.   +1 more
core   +1 more source