Results 151 to 160 of about 157,687 (296)

Research on Deformation Prediction of Small Interval Tunnel Based on Machine Learning and Numerical Simulation

Energy Science &Engineering, EarlyView.
This study leverages machine learning algorithms—specifically artificial neural networks (ANN) and genetic programming (GP)—to forecast and analyze variations in vault settlement measurements during excavation of small interval tunnel. A settlement prediction model was developed and validated through comparative analysis with regression to evaluate the
Wenjie Zhai, Jia Xue, Yongjie Fu, Beichen Yu, Yan Zhu, Man Yuan, Mingbo Chi, Zhentao Li   +7 more
wiley   +1 more source

Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS-chemokine-myeloid axis. [PDF]

Sci Adv
Beernaert B, Jady-Clark RL, Shah P, Ramon-Gil E, Lawson NM, Brodtman ZD, Tagore S, Stihler F, Carter AS, Clarke S, Liu T, Zhu WM, Martin JE, Erdal E, Easton A, Campo L, Browne M, Ash S, Raja RQ, Waddell N, Crosby T, Lord SR, Mann DA, Melero I, de Andrea CE, Tijhuis AE, Foijer F, Hammond EM, Akdemir KC, Leslie J, Izar B, Parkes EE.   +31 more
europepmc   +2 more sources

It's a kind of MAGIC: uncovering the origins of chromosomal instability. [PDF]

Signal Transduct Target Ther
Gómez-Peregrina D, Serrano C.
europepmc   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

Epigenetic Regulation of Chromosomal Instability by EZH2 Methyltransferase. [PDF]

Cancer Discov
Bai Y, Agustinus AS, Yomtoubian S, Meydan C, McNally DR, Yoffe L, Hubisz MJ, Tranquille M, Pramod S, Hong C, Plasilova ML, Kapoor AR, Singh A, Withers H, Dow LE, Laughney AM, Bhinder B, Elemento O, Melnick AM, Bakhoum SF, Mittal V.   +20 more
europepmc   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Characteristics of chromosomal instability‑related lncRNAs associated with progression and prognosis in breast cancer. [PDF]

Mol Med Rep
Chen Q, Chen H, Yang H, Tao Y, Zhu X.
europepmc   +1 more source

Immune, molecular and genetic profiles of gastric signet ring cell carcinoma: Recent progress and future challenges

International Journal of Cancer, EarlyView.
Abstract Gastric signet ring cell carcinoma (GSRCC) is a special type of gastric cancer common in young women. Diffuse gastric cancer (DGC) begins with intramucosal lesions comprising differentiated GSRCC cells. Genetically, GSRCC and DGC are clonally identical, with their morphology influenced by extracellular Wnt signaling.
Qian Wang, Shuai Zhou, Xiongchao Fang, Xianli He, Gang Wang, Nan Wang   +5 more
wiley   +1 more source

Immunofluorescent microscopy to quantify and characterize chromosomal instability (CIN). [PDF]

Methods Cell Biol
Jones KM, Choi Y, Leelasukseree R, Messick NN, Bryan A, Bice S, Cosper PF.   +6 more
europepmc   +1 more source

Risk of childhood and adolescent, and young adult cancer in offspring of men with testicular cancer: A Danish nationwide study

International Journal of Cancer, EarlyView.
What's New? Testicular germ cell cancer (TC), the most common solid tumor among young men in Western countries, has survival rates exceeding 95 percent, allowing most survivors to pursue fatherhood. Concerns remain, however, about cancer risk in offspring, given potential mutagenic effects incurred during treatment for TC.
Mikkel Bandak, Susanne Rosthøj, Gitte Lerche Aalborg, Jakob Lauritsen, Aleksander Giwercman, Hege Sagstuen Haugnes, Gedske Daugaard, Allan Jensen   +7 more
wiley   +1 more source