Results 171 to 180 of about 157,687 (296)

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza, Lara Rodrigues De Andrade, Tatiana da Silva Souza   +2 more
wiley   +1 more source

Genomic comparisons and the adaptive basis of brain size plasticity and chromosomal instability in the Eurasian common shrew. [PDF]

Mol Biol Evol
Thomas WR, Lama TM, Baldoni C, Marín-Gual L, Moreno Santillán D, Farré M, Abueg L, Balacco J, Fedrigo O, Formenti G, Jain N, Mountcastle J, Tilley T, Sims Y, Tracey A, Wood J, Ray DA, von Elverfeldt D, Nieland J, Corthals AP, Ruiz-Herrera A, Dechmann DKN, Jarvis E, Dávalos LM.   +23 more
europepmc   +1 more source

Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management

Journal of Applied Toxicology, EarlyView.
ABSTRACT Ivermectin is a widely used macrocyclic lactone with established efficacy against a broad range of parasitic infections in humans and animals and a long‐standing reputation for clinical safety. However, increasing evidence indicates that ivermectin can produce clinically relevant toxicity under specific conditions, particularly involving the ...
Serkan Yilmaz, Bayram Göktaş, İlker Ateş, Mustafa Çelik   +3 more
wiley   +1 more source

Chromosomal instability and genomic alterations in cholangiocarcinoma from Northeastern Thailand. [PDF]

J Pathol
Deenonpoe R, Guscott MA, Watcharadetwittaya S, McNeill IL, Moralli D, Shaikh N, McClelland SE.   +6 more
europepmc   +1 more source

Chromosome instability [PDF]

, 2018
openaire   +2 more sources

Exploring the Chemical Complexity and Toxicological Behaviour of Semi‐permanent Make‐Up Pigments: A Systematic Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Semi‐permanent make‐up (SPMU), or micropigmentation, involves implanting pigments into the dermal layer of the skin for cosmetic enhancement. Unlike topical cosmetics, which are rapidly cleared from the body, SPMU pigments persist in living tissues, raising unique toxicological considerations.
T. A. N. Kaye, M. B. Komane, A. P. Manyisane, R. Manganyi   +3 more
wiley   +1 more source

PTEN-deficient, chromosomal instability colorectal cancer is hypersensitive to STAT3 inhibition. [PDF]

Int J Biol Sci
Ren G, Pu Y, Zhang X, Chen J, Yang EJ, Tao S, Chen LJ, Zhu W, Chan KL, Luo G, Deng C, Shim JS.   +11 more
europepmc   +1 more source

The Impact of Genetic Polymorphisms on Genotoxicity (DNA Damage) Among Children Exposed to Environmental Mutagens: A Systematic Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto, Daniel Vitor de Souza, Gabriel Carvalhal de Aguiar, Ana Claudia Muniz Renno, Patricia Ramos Cury, Jean Nunes dos Santos, Rogerio Aparecido Dedivitis, Daniel Araki Ribeiro   +7 more
wiley   +1 more source

A system-level metastable model of cancer evolution: integrating replication stress, cell cycle deregulation and chromosomal instability. [PDF]

Ann Med
Ma D, Wang J, Chen Y, Yao L, Wei Q, Wu J.   +5 more
europepmc   +1 more source