Results 181 to 190 of about 93,154 (303)

Rising Incidence and Mortality of Colorectal Cancer Among Younger Adults: A Population‐Based Study in Taiwan, 1994–2018

International Journal of Cancer, EarlyView.
Colorectal cancer incidence and mortality have increased in the Asia‐Pacific region over the past three decades. This population‐based study in Taiwan suggests a shift of the colorectal cancer burden towards the younger generations. An age–period–cohort model revealed higher annual increases in incidence (3.58%) and mortality (1.0%) rates among ...
Yun‐Chen Tsai, Chih‐Yi Wu, Tsung‐I Hung, Hung‐Yi Chiou   +3 more
wiley   +1 more source

Immunofluorescent microscopy to quantify and characterize chromosomal instability (CIN). [PDF]

Methods Cell Biol
Jones KM, Choi Y, Leelasukseree R, Messick NN, Bryan A, Bice S, Cosper PF.   +6 more
europepmc   +1 more source

Predictive Biomarkers in Metastatic Colorectal Cancer Patients Treated With Bevacizumab: A Turkish Oncology Group (TOG) Study

International Journal of Cancer, EarlyView.
Bevacizumab added to systemic chemotherapy remains a cornerstone of metastatic colorectal cancer treatment, but its effectiveness is variable. Tumors can bypass the VEGF blockade by activating other pro‐angiogenic pathways, hampering the identification of predictive biomarkers.
Büsra Akay Hacan, Fatma Gizem Sonugür, Müge Öçal, Cansu Babahan, Samira Abgarmi, Ülkü Yalçıntaş Arslan, Mehmet Ali Şendur, Ahmet Demirkazık, Güngör Utkan, Hakan Akbulut   +9 more
wiley   +1 more source

Surprisingly frequent chromosomal instability in cultivated peanut. [PDF]

Plant J
Lamon S, Abernathy BL, Leal-Bertioli SCM, Bertioli DJ, Bertioli DJ.   +4 more
europepmc   +1 more source

Gender‐based violence during pregnancy and adverse perinatal outcomes in an urban low‐ and middle‐income setting: A prospective cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To evaluate the association between gender‐based violence (GBV) assessed in early pregnancy and adverse perinatal outcomes using relative and absolute effect measures in an urban low‐ and middle‐income setting. Methods We conducted a prospective cohort study including 3890 singleton pregnancies recruited from two public healthcare ...
Elsa Romelia Moreno‐Verduzco, Javier Perez Duran, Irma Eloisa Monroy‐Muñoz, Juan Mario Solis‐Paredes, Salvador Espino‐y‐Sosa, Raigam Martinez‐Portilla, Johnatan Torres‐Torres   +6 more
wiley   +1 more source

Chromosomal instability as a predictive biomarker for recurrence risk following transurethral resection of NMIBC. [PDF]

Front Oncol
Ding Q, Zhu H, Fan B, Wang L, Jin X, Cao C, Shi Y, Fan Z, Tu W, Li F.   +9 more
europepmc   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS-chemokine-myeloid axis. [PDF]

Sci Adv
Beernaert B, Jady-Clark RL, Shah P, Ramon-Gil E, Lawson NM, Brodtman ZD, Tagore S, Stihler F, Carter AS, Clarke S, Liu T, Zhu WM, Martin JE, Erdal E, Easton A, Campo L, Browne M, Ash S, Raja RQ, Waddell N, Crosby T, Lord SR, Mann DA, Melero I, de Andrea CE, Tijhuis AE, Foijer F, Hammond EM, Akdemir KC, Leslie J, Izar B, Parkes EE.   +31 more
europepmc   +2 more sources

Proteostasis failure and mitochondrial dysfunction contribute to chromosomal instability-induced microcephaly. [PDF]

Nat Commun
González-Blanco A, Acuña-Higaki A, Boettger D, Joy J, Milán M.   +4 more
europepmc   +1 more source

Metabolic feature profiling and metabolic vulnerability in acute lymphoblastic leukemia

Interdisciplinary Medicine, EarlyView.
For the first time, our study develops a novel metabolic classification and subtyping program, metabolic reprogramming‐based classifier for acute lymphoblastic leukemia, using internal PDT‐ALL‐2016 and external cohorts, which dissects metabolic profiling, clinical outcome, and therapeutic vulnerability for precision metabolic intervention in ALL ...
Xiaojie Liang, Zihong Cai, Bingqing Tang, Zicong Huang, Baiwei Luo, Bingyu Lin, Yunong Yang, Zhihao Jin, Xiaoqing Li, Xiuli Xu, Yeling Deng, Chaoran Lin, Liang Wang, Hongsheng Zhou   +13 more
wiley   +1 more source