Results 161 to 170 of about 86,167 (192)

Defining ‘chromosomal instability’

Trends in Genetics, 2008
Most scientists agree that the majority of human solid malignant tumors are characterized by chromosomal instability (CIN) involving gain or loss of whole chromosomes or fractions of chromosomes. CIN is thought to be an early event during tumorigenesis and might therefore be involved in tumor initiation.
Jochen B, Geigl, Anna C, Obenauf, Thomas, Schwarzbraun, Michael R, Speicher   +3 more
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Chromosome Instability Syndromes

1989
The chromosome instability syndromes represent a group of heritable disorders that share the common characteristics of increased spontaneous or induced chromosome breakage, hypersensitivity to various physical and chemical agents, and a predisposition to the development of neoplasia. Each syndrome has a distinct phenotype, although significant clinical
M M, Cohen, H P, Levy
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Chromosomal Instability

Current Opinion in Oncology, 2004
This review discusses numerical and structural chromosomal instability in cancer cells and its possible etiologies, highlighting the recent literature.Defects in chromosomal segregation, telomere stability, and the DNA damage response play significant roles in chromosomal instability in cancer.The pace of discoveries into the biologic basis of ...
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Telomeres and chromosomal instability

Cellular and Molecular Life Sciences (CMLS), 2004
Telomeres are distinctive structures, composed of a repetitive DNA sequence and associated proteins, which enable cells to distinguish chromosome ends from DNA double-strand breaks. Telomere alterations, caused by replication-mediated shortening, direct damage or defective telomere-associated proteins, usually generate chromosomal instability, which is
N, Mathieu, L, Pirzio, M-A, Freulet-Marrière, C, Desmaze, L, Sabatier   +4 more
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Telomeres and chromosome instability

DNA Repair, 2006
Genomic instability has been proposed to play an important role in cancer by accelerating the accumulation of genetic changes responsible for cancer cell evolution. One mechanism for chromosome instability is through the loss of telomeres, which are DNA-protein complexes that protect the ends of chromosomes and prevent chromosome fusion.
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Chromosome Instability Syndromes

1993
Several mutant genes are known that greatly increase the incidence of chromosome aberrations and have striking clinical effects. The most extensively studied of these autosomal recessive disorders are Bloom syndrome (BS), Fanconi anemia (FA), and ataxia telangiectasia (AT).
Eeva Therman, Millard Susman
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Possible hereditary Y‐chromosome instability

Pediatrics International, 1994
AbstractA 9 year old boy, born to a phenotypically normal, non‐consanguineous couple was referred for clinical examination due to radio‐ulnar synostosis. We made cytogenetic analyses to investigate the genotype‐phenotype correlation. Chromosomal studies on the boy and his father revealed a very small Y chromosome in both cases, probably due to loss of ...
E, Zeniya, K, Iinuma, M, Kato
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Chromosome instability syndromes

1992
Abstract A number of clinically diverse inherited human diseases, unified by the abnormal behaviour of their chromosomes, are sometimes grouped together under the heading of chromosome instability syndromes. Depending on the syndrome, the abnormal chromosome behaviour may take the form of:
R T Howell, A M R Taylor
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Chromosome Instability Syndromes

2018
Abstract A defect of DNA repair is the factor underlying the chromosome instability syndromes, also known as chromosome breakage syndromes. The “instability” refers to the predisposition of the chromosomes to undergo rearrangement or to display other abnormal cytogenetic behavior.
R. J McKinlay Gardner, David J Amor
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