Results 171 to 180 of about 86,167 (192)
Some of the next articles are maybe not open access.
Chromosomal instability in bladder cancer
Archives of Toxicology, 2008Chromosomal instability (CIN) distinguishes invasive urothelial carcinomas from less malignant papillary subtypes. Recent results implicate checkpoint dysfunction as a crucial factor underlying the emergence of aneuploidy in urothelial carcinogenesis. It may moreover contribute to DNA repair defects.
Andrea R, Florl, Wolfgang A, Schulz
openaire +2 more sources
Chromosome Instability Syndromes
2011Abstract A DEFECT OF DNA repair is the factor underlying the chromosome instability syndromes, also known as chromosome breakage syndromes (Brewer et al., 1997; Michelson and Weinert, 2000; Taylor, 2001). The “instability” refers to the predisposition of the chromosomes to undergo rearrangement or to display other abnormal cytogenetic
R. J. McKinlay Gardner +2 more
openaire +1 more source
[Chromosome instability syndromes].
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1983Chromosome instability syndromes are defined by either an increase of chromosomal breakage or by an increase of sister chromatid exchange number, or by an increase of the two. Bloom's syndrome, Ataxia telangiectasia, Fanconi's Anemia are the main components of this group. The incidence of cancers or malignant blood diseases is high.
D, Germain, A, Bernheim
openaire +2 more sources
[Chromosome instability syndromes].
Casopis lekaru ceskych, 2002We refer 55 cases of the chromosomal instability syndromes (SCI), diagnosed in patients of our genetical clinics. Problems of early diagnosis can be documented by a discrepancy between the expected number of patients and their relative advanced age at the time when SCI was ascertained.
E, Seemanová, P, Seeman, P, Jarolím
openaire +1 more source
Genetically determined chromosome instability syndromes
Cytogenetic and Genome Research, 1982Spontaneously increased chromosomal instability is well documented in the three autosomal recessive diseases, Fanconi’s anemia (FA), Bloom’s syndrome (BS), and ataxia telangiectasia (AT). Other conditions have been reported to be associated with chromosomal breakage. Some are still single observations: in Werner’s syndrome only fibroblasts are affected,
openaire +2 more sources
[Chromosome instability syndromes].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2006Defects of DNA repair underlie genetic syndromes. Chromosomal aberrations and mutations might cause specific inborn defects. There are several syndromes with characteristic clinical features, which appear to be caused by chromosome instability which is a consequence of DNA repair defects.
Agnieszka, Tomaszewska +2 more
openaire +1 more source
Chromosome Breaks and Genomic Instability
Cancer Investigation, 2000Tumorigenesis is known to result from multiple genetic changes. Although endogenous and environmental insults can damage DNA, cellular mechanisms exist to repair various forms of damage or to kill those cells irreparably damaged. Hence, the accumulation of numerous genetic changes that would lead to cancer in normal cells is extremely rare ...
openaire +2 more sources
Spontaneous chromosomal instability
Human Genetics, 1973Traute M. Schroeder, Eberhard Passarge
openaire +3 more sources