Causes of Chromosomal Instability
, 2015 The majority of human cancer cells are highly aneuploid harboring chromosome numbers deviating from the modal number of 46. In cancer, aneuploidy is a consequence of an increased rate of whole chromosome missegregation during mitosis, a process known as chromosomal instability (CIN).
Bastians, Holger +2 more
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Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution
Cell Reports, 2015 Numerical chromosomal instability is a ubiquitous feature of human neoplasms. Due to experimental limitations, fundamental characteristics of karyotypic changes in cancer are poorly understood.
Ashley M. Laughney +3 more
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Chromosomal aberrations after induced pluripotent stem cells reprogramming
Genetics and Molecular Biology, 2021 Induced pluripotent stem cells (iPSCs) are generated from adult cells that have been reprogrammed to pluripotency. However, in vitro cultivation and genetic reprogramming increase genetic instability, which could result in chromosomal abnormalities ...
Isadora May Vaz +9 more
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Colonic epithelial adaptation to EGFR-independent growth induces chromosomal instability and is accelerated by prior injury [PDF]
, 2021 Tiane Chen +8 more
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Evaluation of predictive biomarkers for late radiation toxicity in breast cancer patients
Scientific ReportsRadiotherapy is administered to 70% of breast cancer patients, but late complications such as breast fibrosis remain a significant clinical concern. Individual variability significantly influences radiosensitivity, underscoring the need for predictive ...
Ángela Solana-Peña +14 more
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The impact of monosomies, trisomies and segmental aneuploidies on chromosomal stability.
PLoS ONE, 2022 Aneuploidy and chromosomal instability are both commonly found in cancer. Chromosomal instability leads to karyotype heterogeneity in tumors and is associated with therapy resistance, metastasis and poor prognosis.
Dorine C Hintzen +10 more
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Supplementary Figure 2B from Relationship of Extreme Chromosomal Instability with Long-term Survival in a Retrospective Analysis of Primary Breast Cancer [PDF]
, 2023 Rebecca Roylance +14 more
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Chromosome instability in neuroblastoma.
Oncology letters, 2018 Neuroblastoma is a neural crest-derived tumor that accounts for 7-10% of all malignancies in children and ~15% of all childhood cancer-associated mortalities. Approximately 50% of patients are characterized as high-risk (HR) and have an overall survival of
Fusco, Pina +2 more
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Diagnostic Role of Chromosomal Instability in Melanoma
Journal of Skin Cancer, 2012 Early diagnosis gives melanoma patients the best chance for long term survival. However discrimination of an early melanoma from an unusual/atypical benign nevus can represent a significant challenge.
Nitika Dabas +4 more
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Supplementary Tables 1-2 from Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1 (Rnf20/Rnf40) Leads to Replication Stress and Chromosomal Instability [PDF]
, 2023 Sophia B. Chernikova +11 more
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