Results 51 to 60 of about 86,167 (192)

Clinicopathologic features of colorectal carcinoma: features predicting higher T-stage and nodal metastasis

BMC Research Notes, 2018
Objectives A rising frequency of colorectal carcinoma has been noted in recent years in Pakistan. In the present study, we aimed to evaluate clinicopathologic features of colorectal carcinoma in our population so that protocols could be developed to ...
Atif Ali Hashmi, Shumaila Kanwal Hashmi, Navaira Ali, Komal Thara, Rabia Ali, Muhammad Muzzammil Edhi, Naveen Faridi, Amir Khan   +7 more
doaj   +1 more source

A new insight into the impact of copy number variations on cell cycle deregulation of luminal-type breast cancer

Oncology Reviews
Breast cancer is the most prevalent neoplasm in women. ER+ (Luminal subtype), representing over 70% of breast tumors, is a genetically diverse group. Structural and Numerical-Chromosomal instability initiates tumor development and is recognized as the ...
Amir Mahdi Khamaneh, Davoud Jafari-Gharabaghlou, Khalil Ansarin, Khalil Ansarin, Khalil Ansarin, Pouya Pazooki, Zahra Akbarpour, Behrooz Naghili, Behrooz Naghili, Nosratollah Zarghami, Nosratollah Zarghami   +10 more
doaj   +1 more source

Chromosomal instability in Streptomyces avermitilis: major deletion in the central region and stable circularized chromosome

BMC Microbiology, 2010
Background The chromosome of Streptomyces has been shown to be unstable, frequently undergoing gross chromosomal rearrangements. However, the mechanisms underlying this phenomenon remain unclear, with previous studies focused on two chromosomal ends as ...
Wen Ying, Chen Zhi, Zhang Xiaojuan, He Fei, Chen Wei, Li Jilun   +5 more
doaj   +1 more source

Common fragile sites: protection and repair

Cell & Bioscience, 2020
Common fragile sites (CFSs) are large chromosomal regions that exhibit breakage on metaphase chromosomes upon replication stress. They become preferentially unstable at the early stage of cancer development and are hotspots for chromosomal rearrangements
Shibo Li, Xiaohua Wu
doaj   +1 more source

Microsatellite instability induced mutations in DNA repair genes CtIP and MRE11 confer hypersensitivity to poly (ADP-ribose) polymerase inhibitors in myeloid malignancies

Haematologica, 2013
Inactivation of the DNA mismatch repair pathway manifests as microsatellite instability, an accumulation of mutations that drives carcinogenesis. Here, we determined whether microsatellite instability in acute myeloid leukemia and myelodysplastic ...
Terry J. Gaymes, Azim M. Mohamedali, Miranda Patterson, Nazia Matto, Alexander Smith, Austin Kulasekararaj, Rajani Chelliah, Nicola Curtin, Farzin Farzaneh, Sydney Shall, Ghulam J. Mufti   +10 more
doaj   +1 more source

Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality

Cell Reports, 2018
Summary: PICH is a DNA translocase necessary for the resolution of ultrafine anaphase DNA bridges and to ensure the fidelity of chromosomal segregation.
Eliene Albers, Mauro Sbroggiò, David Pladevall-Morera, Anna H. Bizard, Alexandra Avram, Patricia Gonzalez, Javier Martin-Gonzalez, Ian D. Hickson, Andres J. Lopez-Contreras   +8 more
doaj   +1 more source

Chromosomal instability in ataxia telangiectasia

Cancer Genetics and Cytogenetics, 1982
We have examined various aspects of lymphocyte chromosomal instability in three families comprised of five individuals affected with ataxiatelangiectasia (AT), their obligate heterozygous parents, and their unaffected sibs. We found that neither baseline sister chromatid exchanges (SCEs) nor mitomycin-C-induced increments in SCEs showed any significant
Department of Pediatrics, University of Florida, Gainesville, Florida USA. ( host institution ), Kohn, P.H. ( author ), Whang-Peng, J. ( author ), Levis, W.R. ( author )   +3 more
openaire   +3 more sources

Long noncoding RNA, PURPL is associated with aneuploidy and its magnitude of expression level is dependent on P53 status

Frontiers in Cell and Developmental Biology
IntroductionLong non-coding RNAs (lncRNAs) are a fascinating, but still largely uncharacterized, class of genes. Recently, lncRNAs have attracted significant attention due to their emerging functions in development and disease.
Pushkar Malakar
doaj   +1 more source

Breast tumor copy number aberration phenotypes and genomic instability

BMC Cancer, 2006
Background Genomic DNA copy number aberrations are frequent in solid tumors, although the underlying causes of chromosomal instability in tumors remain obscure. Genes likely to have genomic instability phenotypes when mutated (e.g.
Ljung Britt, Tokuyasu Taku, Dairkee Shanaz, Segraves Richard, Olshen Adam, Li Hua, Ylstra Bauke, Snijders Antoine M, Fridlyand Jane, Jain Ajay N, McLennan Jane, Ziegler John, Chin Koei, Devries Sandy, Feiler Heidi, Gray Joe W, Waldman Frederic, Pinkel Daniel, Albertson Donna G   +18 more
doaj   +1 more source

Cancer tolerance to chromosomal instability is driven by Stat1 inactivation in vivo [PDF]

, 2021
Michaël Schubert, Christy Hong, Laura J. Jilderda, Marta Requesens, Andréa E. Tijhuis, Judith E. Simon, Petra L. Bakker, Jon L. Cooper, Aristi Damaskou, René Wardenaar, Björn Bakker, Sahil Gupta, Anouk van den Brink, Lorena Andrade Ruiz, Miriam H. Koster, Sameh A. Youssef, Daniëlle Luinenburg, Alex Strong, Thomas Engleitner, Hannes Ponstingl, Gerald de Haan, Alain de Bruin, Roland Rad, Hans W. Nijman, René H. Medema, Marcel A.T.M. van Vugt, Marco de Bruyn, Diana C.J. Spierings, Maria Colomé‐Tatché, George S. Vassiliou, Floris Foijer   +30 more
openalex   +1 more source