Results 151 to 160 of about 92,482 (260)

Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders

Medicinal Research Reviews, EarlyView.
ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar, Tobias Werner, Mihajlo Gajic, Holger Stark, Bassem Sadek   +4 more
wiley   +1 more source

Molecular Mechanisms in the Carcinogenesis of Oral Squamous Cell Carcinoma: A Literature Review. [PDF]

Biomolecules
Cabral LGS, Martins IM, Paulo EPA, Pomini KT, Poyet JL, Maria DA.   +5 more
europepmc   +1 more source

LINC00922: A Critical Oncogenic Long Non‐Coding RNA Involved in Cancer Progression, Chemotherapy Resistance, and microRNA Regulation

Medicine Advances, EarlyView.
LINC00922 is located at 16q21 and is primarily expressed in the cytoplasm. It has been implicated in promoting tumor progression, contributing to poor overall survival (OS) and disease‐free survival (DFS) in patients. LINC00922 drives cancer progression through a complex network of gene interactions, enhances chemotherapy resistance in cancer cells ...
Jiahua Si, Chenhao Liang, Xueting Zhang, Hening Xu, Xinming Su, Luqing Liu, Ruyi Yuan, Yuemin Ding, Shiwei Duan   +8 more
wiley   +1 more source

PGC‐1α Activation by Polyphenols: A Pathway to Thermogenesis

Molecular Nutrition &Food Research, EarlyView.
Polyphenols, derived from dietary sources such as berries, undergo digestion and interact with gut microbiota, leading to their metabolization in the liver. This process influences bile acid composition, which in turn activates PGC1α, a key regulator of mitochondrial biogenesis and thermogenesis.
Nicholas Vannuchi, Luciana Pisani
wiley   +1 more source

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

H3K27me3 and the PRC1-H2AK119ub pathway cooperatively maintain heterochromatin and transcriptional silencing after the loss of H3K9 methylation. [PDF]

Epigenetics Chromatin
Fukuda K, Shimura C, Shinkai Y.
europepmc   +1 more source

Plasticity of Gene Expression in Spaceflight and Postflight in Relation to Cardiovascular Disease: Mechanisms and Candidate Repurposed Drugs

PROTEOMICS, EarlyView.
ABSTRACT Spaceflight poses unique challenges to human health due to exposure to increased levels of cosmic radiation, microgravity, and associated oxidative stress. These environmental factors can lead to cellular damage, inflammation, and a range of health complications, including cardiovascular problems, immune system impairment, and an increased ...
Marilena M. Bourdakou, Eleni M. Loizidou, George M. Spyrou   +2 more
wiley   +1 more source

Epigenomic Echoes-Decoding Genomic and Epigenetic Instability to Distinguish Lung Cancer Types and Predict Relapse. [PDF]

Epigenomes
Baumann AA, Buribayev Z, Wolkenhauer O, Salybekov AA, Wolfien M.   +4 more
europepmc   +1 more source

Quantitative changes of high mobility group non‐histone chromosomal proteins HMG1 and HMG2 during rooster spermatogenesis

FEBS Letters, 1983
M. Chiva, C. Mezquita
semanticscholar   +1 more source

POCALI: Prediction and Insight on CAncer LncRNAs by Integrating Multi‐Omics Data with Machine Learning

Small Methods, EarlyView.
Long non‐coding RNAs (lncRNAs) are receiving increasing attention as biomarkers for cancer diagnosis and therapy, highlighting the urgent need for computational methods to accelerate their comprehensive discovery. Here, to better predict and provide functional insight into cancer lncRNAs, a novel interpretable machine‐learning method (POCALI) is ...
Ziyan Rao, Chenyang Wu, Yunxi Liao, Chuan Ye, Shaodong Huang, Dongyu Zhao   +5 more
wiley   +1 more source