Results 151 to 160 of about 11,541,999 (289)

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source

The Mutational Landscape of Acute Myeloid Leukemia and Its Impact. [PDF]

Int J Mol Sci
Ratnayake T, Liongue C, Ward AC.
europepmc   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

SCP4 dephosphorylates mitotic histone H3 to maintain chromosome stability. [PDF]

EMBO Rep
Zheng Y, Zhang Z, Wang Q, Cao J, Li Y, Liang T, Feng XH, Lin X.   +7 more
europepmc   +1 more source

The isolation of the high mobility group non‐histone chromosomal protein HMG 14 [PDF]

FEBS Letters, 1977
Goodwin, Graham H., Rabbani, Azra, Nicolas, Robert H., Johns, Ernest W.   +3 more
openaire   +2 more sources

Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications

Portal Hypertension &Cirrhosis, EarlyView.
This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf, Mahboobeh Ebrahimi Varkiani, Saeid Abroun, Pedram Asadi‐Sarabi, Shukoofeh Torabi, Elham Rismani, Mohammad Majd Hammour, Andreas K. Nüssler, Massoud Vosough   +8 more
wiley   +1 more source

Proteolysis Targeting Chimeric-Based Technology in Myeloma and Lymphoma. [PDF]

Mol Cancer Ther
Tigu AB, Ivancuta A, Tomuleasa C, Nistor M, Kegyes D, Cenariu D, Munteanu R, Buzoianu AD, Einsele H, Federico M, Kobold S, Gulei D, Ciechanover A.   +12 more
europepmc   +1 more source

Gene turnover in the common ancestor of all C4 grasses

PLANTS, PEOPLE, PLANET, EarlyView.
Understanding how plants evolve more efficient photosynthesis is important in a warming world where improving crop productivity and resilience is a global priority. By generating the first reference genomes for an early‐diverging group of grasses called the Aristidoideae, we were able to reconstruct the genetic makeup of the last common ancestor of all
Lara Pereira, Ahmed S. Alenazi, Sahr Mian, Ilia J. Leitch, Pascal‐Antoine Christin, Colin P. Osborne, Luke T. Dunning   +6 more
wiley   +1 more source

Current insights into PHF14: molecular features and functional roles. [PDF]

Front Mol Biosci
Gopalakrishnan V, Fahma A, Raju R, Soman S.   +3 more
europepmc   +1 more source

Studies on histones and non-histone proteins from rats treated with dimethylnitrosamine

, 1979
A study has been made of the histone and non-histone chromosomal proteins of rat liver after treatment in vivo with dimethylnitrosamine (DMN) (2 mg/kg). DMN was found not to affect histone turnover, as measured by 3H-labelled amino-acids incorporation. A
Galbraith, A., Itzhaki, Ruth F.
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