Results 101 to 110 of about 1,002,198 (296)

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

Checkpoints are blind to replication restart and recombination intermediates that result in gross chromosomal rearrangements

Nature Communications, 2015
Replication fork inactivation can be overcome by homologous recombination, but this can cause gross chromosomal rearrangements that subsequently missegregate at mitosis, driving further chromosome instability.
S. Mohebi, K. Mizuno, A. Watson, A. Carr, J. Murray   +4 more
semanticscholar   +1 more source

Principles of genome evolution in the Drosophila melanogaster species group.

, 2007
That closely related species often differ by chromosomal inversions was discovered by Sturtevant and Plunkett in 1926. Our knowledge of how these inversions originate is still very limited, although a prevailing view is that they are facilitated by ...
Marcin von Grotthuss, Yuk S Chan, José M Ranz, Damien Maurin, Michael Ashburner, Casey M Bergman, LaDeana W Hillier, John Roote   +7 more
core   +1 more source

Phylogenetic inferences of Atelinae (Platyrrhini) based on multi-directional chromosome painting in Brachyteles arachnoides, Ateles paniscus paniscus and Ateles b. marginatus [PDF]

, 2005
We performed multi-directional chromosome painting in a comparative cytogenetic study of the three Atelinae species Brachyteles arachnoides, Ateles paniscus paniscus and Ateles belzebuth marginatus, in order to reconstruct phylogenetic relationships ...
de Oliveira, EHC, Müller, Stefan, Neusser, M., Nagamachi, C., Sbalqueiro, I. J., Pieczarka, J. C.   +5 more
core   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Enhancing recombinant protein production through Cre-loxP mediated chromosomal rearrangement evolution in Kluyveromyces marxianus

Communications Biology
Chromosomal rearrangements can drive adaptive evolution; however, whether the rearrangements in non-coding and non-promoter regions can lead to new phenotypes under selective pressures remains unclear.
Haiyan Ren, Qiyuan Zou, Kunfeng Song, Yao Yu, Jungang Zhou, Wenjuan Mo, Hong Lu   +6 more
doaj   +1 more source

Recent advances in the detection technologies for balanced chromosomal rearrangements

Frontiers in Genetics
Balanced chromosomal rearrangements (BCRs) refer to a type of chromosomal structural variations without chromosomal gains or losses. BCR carriers may experience fertility issues, including a higher risk of infertility, recurrent miscarriages, or having ...
Meng Gao, Meng Gao, Jun Ren, Jun Ren, Shanling Liu, Shanling Liu   +5 more
doaj   +1 more source

Vietnam, a Hotspot for Chromosomal Diversity and Cryptic Species in Black Flies (Diptera: Simuliidae).

PLoS ONE, 2016
The increasing attention on Vietnam as a biodiversity hotspot prompted an investigation of the potential for cryptic diversity in black flies, a group well known elsewhere for its high frequency of isomorphic species. We analyzed the banding structure of
Peter H Adler, Hiroyuki Takaoka, Mohd Sofian-Azirun, Van Lun Low, Zubaidah Ya'cob, Chee Dhang Chen, Koon Weng Lau, Xuan Da Pham   +7 more
doaj   +1 more source

Chromosomal Rearrangements in Salmonella enterica Serovar Typhi Strains Isolated from Asymptomatic Human Carriers

mBio, 2011
Host-specific serovars of Salmonella enterica often have large-scale chromosomal rearrangements that occur by recombination between rrn operons. Two hypotheses have been proposed to explain these rearrangements: (i) replichore imbalance from horizontal ...
T. David Matthews, Wolfgang Rabsch, Stanley Maloy   +2 more
doaj   +1 more source

In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system

Nature, 2014
Chromosomal rearrangements have a central role in the pathogenesis of human cancers and often result in the expression of therapeutically actionable gene fusions.
Danilo Maddalo, Eusebio Manchado, Carla P. Concepcion, Ciro Bonetti, Joana A. Vidigal, Yoon-Chi Han, Paul Ogrodowski, A. Crippa, N. Rekhtman, E. de Stanchina, S. Lowe, A. Ventura   +11 more
semanticscholar   +1 more source