Results 81 to 90 of about 1,114,920 (242)
Cell & Bioscience, 2016 Genetic aberrations have been identified in nasopharyngeal carcinoma (NPC), however, the underlying mechanism remains elusive. There are increasing evidences that the apoptotic nuclease caspase-activated deoxyribonuclease (CAD) is one of the players ...
Sang-Nee Tan, S. Sim, A. Khoo
semanticscholar +1 more source
Chromosomal rearrangement interferes with meiotic X chromosome inactivation [PDF]
Genome Research, 2007 Heterozygosity for certain mouse and human chromosomal rearrangements is characterized by the incomplete meiotic synapsis of rearranged chromosomes, by their colocalization with the XY body in primary spermatocytes, and by male-limited sterility. Previously, we argued that such X–autosomal associations could interfere with meiotic sex chromosome ...
David, Homolka +4 more
openaire +2 more sources
Tracing cancer evolution and heterogeneity using Hi-C
Nature Communications, 2023 Chromosomal rearrangements can initiate and drive cancer progression, yet it has been challenging to evaluate their impact, especially in genetically heterogeneous solid cancers.
Dan Daniel Erdmann-Pham +10 more
doaj +1 more source
Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis [PDF]
, 2012 To examine the role of hepatitis B virus (HBV) integration in hepatocarcinogenesis, a systematic comparative study of both tumor and their corresponding non-tumor derived tissue has been conducted in a cohort of 60 HBV associated hepatocellular carcinoma
Chun-Ming Wong +13 more
core +3 more sources
Frontiers in Genetics, 2016 Palindromic DNA sequences, which can form secondary structures, are widely distributed in the human genome. Although the nature of the secondary structure—single-stranded “hairpin” or double-stranded “cruciform”—has been extensively investigated in vitro,
H. Inagaki +5 more
semanticscholar +1 more source
Genome BiologyChromosomal rearrangements, such as translocations, deletions, and inversions, underlie numerous genetic diseases and cancers, yet precise engineering of these rearrangements remains challenging.
Mingyao Wang +6 more
doaj +1 more source
Molecular and classical cytogenetic analyses demonstrate an apomorphic reciprocal chromosomal translocation in Gorilla gorilla [PDF]
, 1992 The existence of an apomorphic reciprocal chromosomal translocation in the gorilla lineage has been asserted or denied by various cytogeneticists. We employed a new molecular cytogenetic strategy (chromosomal in situ suppression hybridization) combined ...
Bigoni, F. +5 more
core +1 more source
A case of complex balanced chromosomal translocations associated with adverse pregnancy outcomes
Molecular Cytogenetics, 2022 Complex chromosomal rearrangements (CCR) are rare chromosomal structural abnormalities. The chromosomal structural variants in CCR carriers are one of the factors contributing to a history of adverse pregnancy and childbirth.
Yan Luo +5 more
doaj +1 more source
Three-dimensional genome architecture influences partner selection for chromosomal translocations in human disease. [PDF]
PLoS ONE, 2012 Chromosomal translocations are frequent features of cancer genomes that contribute to disease progression. These rearrangements result from formation and illegitimate repair of DNA double-strand breaks (DSBs), a process that requires spatial ...
Jesse M Engreitz +2 more
doaj +1 more source
Genome reorganization in different cancer types: detection of cancer specific breakpoint regions [PDF]
, 2019 Background: Tumorigenesis is a multi-step process which is accompanied by substantial changes in genome organization. The development of these changes is not only a random process, but rather comprise specific DNA regions that are prone to the ...
Klein, Andreas +3 more
core +1 more source