Results 91 to 100 of about 1,114,920 (242)

In silico karyotyping of chromosomally polymorphic malaria mosquitoes in the Anopheles gambiae complex [PDF]

, 2019
Chromosomal inversion polymorphisms play an important role in adaptation to environmental heterogeneities. For mosquito species in the Anopheles gambiae complex that are significant vectors of human malaria, paracentric inversion polymorphisms are ...
Besansky, N. J., Caputo, B., Della Torre, A., Love, R. R., Petrarca, V., Pombi, M., Redmond, S. N., The Anopheles gambiae1000 Genomes, Consortium   +7 more
core   +1 more source

A versatile reporter system for CRISPR-mediated chromosomal rearrangements

Genome Biology, 2015
Although chromosomal deletions and inversions are important in cancer, conventional methods for detecting DNA rearrangements require laborious indirect assays.
Yingxiang Li, Angela I. Park, Haiwei Mou, Cansu Colpan, Aizhan Bizhanova, Elliot H. Akama-Garren, Nikhil S. Joshi, E. Hendrickson, D. Feldser, Hao Yin, Daniel G. Anderson, T. Jacks, Z. Weng, Wen Xue   +13 more
semanticscholar   +1 more source

The molecular basis of T cell acute lymphoblastic leukemia [PDF]

, 2012
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and ...
Adolfo Ferrando, Bash, Bash, Chen, Condorelli, Dube, Fisch, Hagemeijer, Hebert, Ho, Kelliher, Kikuchi, Larson, Lu, McGuire, McGuire, Nagel, Ntziachristos, Ntziachristos, Ono, Pieter Van Vlierberghe, Royer-Pokora, Rubnitz, van Grotel   +23 more
core   +1 more source

Checkpoints are blind to replication restart and recombination intermediates that result in gross chromosomal rearrangements

Nature Communications, 2015
Replication fork inactivation can be overcome by homologous recombination, but this can cause gross chromosomal rearrangements that subsequently missegregate at mitosis, driving further chromosome instability.
S. Mohebi, K. Mizuno, A. Watson, A. Carr, J. Murray   +4 more
semanticscholar   +1 more source

Enhancing recombinant protein production through Cre-loxP mediated chromosomal rearrangement evolution in Kluyveromyces marxianus

Communications Biology
Chromosomal rearrangements can drive adaptive evolution; however, whether the rearrangements in non-coding and non-promoter regions can lead to new phenotypes under selective pressures remains unclear.
Haiyan Ren, Qiyuan Zou, Kunfeng Song, Yao Yu, Jungang Zhou, Wenjuan Mo, Hong Lu   +6 more
doaj   +1 more source

Vietnam, a Hotspot for Chromosomal Diversity and Cryptic Species in Black Flies (Diptera: Simuliidae).

PLoS ONE, 2016
The increasing attention on Vietnam as a biodiversity hotspot prompted an investigation of the potential for cryptic diversity in black flies, a group well known elsewhere for its high frequency of isomorphic species. We analyzed the banding structure of
Peter H Adler, Hiroyuki Takaoka, Mohd Sofian-Azirun, Van Lun Low, Zubaidah Ya'cob, Chee Dhang Chen, Koon Weng Lau, Xuan Da Pham   +7 more
doaj   +1 more source

Chromosomal Rearrangements in Salmonella enterica Serovar Typhi Strains Isolated from Asymptomatic Human Carriers

mBio, 2011
Host-specific serovars of Salmonella enterica often have large-scale chromosomal rearrangements that occur by recombination between rrn operons. Two hypotheses have been proposed to explain these rearrangements: (i) replichore imbalance from horizontal ...
T. David Matthews, Wolfgang Rabsch, Stanley Maloy   +2 more
doaj   +1 more source

The Potential Of High-Resolution BAC-FISH In Banana Breeding [PDF]

, 2009
The genetic complexity in the genus Musa has been subject of study in many breeding programs worldwide. Parthenocarpy, female sterility, polyploidy in different cultivars and limited amount of genetic and genomic information make the production of new ...
Capdeville, G., De, Eugenio Cardamone Diniz, L., Jong, J.H.S.G.M., de, Kema, G.H.J., Souza, M.T., Swennen, R., Szinay, D., Wijnker, T.G.   +7 more
core   +2 more sources

Large Chromosomal Rearrangements during a Long-Term Evolution Experiment with Escherichia coli

mBio, 2014
Large-scale rearrangements may be important in evolution because they can alter chromosome organization and gene expression in ways not possible through point mutations.
Colin Raeside, J. Gaffé, Daniel E. Deatherage, O. Tenaillon, A. Briska, R. Ptashkin, S. Cruveiller, C. Médigue, R. Lenski, Jeffrey E. Barrick, D. Schneider   +10 more
semanticscholar   +1 more source

Incomplete Sterility of Chromosomal Hybrids: Implications for Karyotype Evolution and Homoploid Hybrid Speciation

Frontiers in Genetics, 2020
Heterozygotes for major chromosomal rearrangements such as fusions and fissions are expected to display a high level of sterility due to problems during meiosis. However, some species, especially plants and animals with holocentric chromosomes, are known
Vladimir A. Lukhtanov, Vlad Dincă, Vlad Dincă, Magne Friberg, Roger Vila, Christer Wiklund   +5 more
doaj   +1 more source