Results 21 to 30 of about 131,087 (254)

The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast. [PDF]

, 2014
DNA double-strand breaks (DSBs) can cause chromosomal rearrangements and extensive loss of heterozygosity (LOH), hallmarks of cancer cells. Yet, how such events are normally suppressed is unclear.
Blaikley, EJ, Bähler, J, Deegan, RS, Hulme, L, Humphrey, TC, Hussey, S, Kasparek, TR, Marguerat, S, Nakagawa, T, Pai, CC, Sarkar, S, Tinline-Purvis, H, Walker, CA, Wee, BY   +13 more
core   +1 more source

Interstitial deletion 4p15.32p16.1 and complex chromoplexy in a female proband with severe neurodevelopmental delay, growth failure and dysmorphism

Molecular Cytogenetics, 2022
Complex chromosomal rearrangements involve the restructuring of genetic material within a single chromosome or across multiple chromosomes. These events can cause serious human disease by disrupting coding DNA and gene regulatory elements via deletions ...
Dong Li, Alanna Strong, Cuiping Hou, Helen Downes, Amanda Barone Pritchard, Pamela Mazzeo, Elaine H. Zackai, Laura K. Conlin, Hakon Hakonarson   +8 more
doaj   +1 more source

Case report: Optical genome mapping revealed double rearrangements in a male undergoing preimplantation genetic testing

Frontiers in Genetics, 2023
Chromosome rearrangement is one of the main causes of abortion. In individuals with double chromosomal rearrangements, the abortion rate and the risk of producing abnormal chromosomal embryos are increased.
Jun Ren, Jun Ren, Jun Ren, Yuezhi Keqie, Yuezhi Keqie, Yuezhi Keqie, Yutong Li, Yutong Li, Yutong Li, Lingping Li, Lingping Li, Lingping Li, Min Luo, Min Luo, Min Luo, Meng Gao, Meng Gao, Meng Gao, Cuiting Peng, Cuiting Peng, Cuiting Peng, Han Chen, Han Chen, Han Chen, Ting Hu, Ting Hu, Ting Hu, Xinlian Chen, Xinlian Chen, Xinlian Chen, Shanling Liu, Shanling Liu, Shanling Liu   +32 more
doaj   +1 more source

MALT1, BCL10 and FOXP1 in salivary gland mucosa-associated lymphoid tissue lymphomas [PDF]

, 2006
In view of the certain anatomic site-dependent frequency of chromosomal translocations involved in extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) pathogenesis, 17 salivary gland MALT lymphoma cases were ...
Isaacson PG, Harris NL, Carbone A, Banham A, Streubel B, Ventura RA, Remstein ED, Baens M, Ye H   +8 more
core   +1 more source

Karyotypic Evolution of the Common and Silverleaf Sunflower Genomes

The Plant Genome, 2009
Silverleaf sunflower ( Torrey and Gray) has been an important source of favorable alleles for broadening genetic diversity and enhancing agriculturally important traits in common sunflower ( L.), and, as the closest living relative of , provides an ...
Adam F. Heesacker, Eleni Bachlava, Robert L. Brunick, John M. Burke, Loren H. Rieseberg, Steven J. Knapp   +5 more
doaj   +1 more source

Comparative studies of X chromosomes in Cervidae family

Scientific Reports, 2023
The family Cervidae is the second most diverse in the infraorder Pecora and is characterized by variability in the diploid chromosome numbers among species.
Anastasia A. Proskuryakova, Ekaterina S. Ivanova, Alexey I. Makunin, Denis M. Larkin, Malcolm A. Ferguson-Smith, Fengtang Yang, Olga V. Uphyrkina, Polina L. Perelman, Alexander S. Graphodatsky   +8 more
doaj   +1 more source

Adenoid cystic carcinoma: emerging role of translocations and gene fusions. [PDF]

, 2016
Adenoid cystic carcinoma (ACC), the second most common salivary gland malignancy, is notorious for poor prognosis, which reflects the propensity of ACC to progress to clinically advanced metastatic disease.
Brait, Mariana, Ha, Patrick K, Izumchenko, Evgeny, Meir, Juliet, Sidransky, David, Wysocki, Piotr T   +5 more
core   +3 more sources

The origin of human chromosome 2 analyzed by comparative chromosome mapping with a DNA microlibrary [PDF]

, 1994
Fluorescencein situ hybridization (FISH) of microlibraries established from distinct chromosome subregions can test the evolutionary conservation of chromosome bands as well as chromosomal rearrangements that occurred during primate evolution and will ...
A Baldini, A Jauch, A. Jauch, B Dutrillaux, B. Horsthemke, C Lengauer, C Lengauer, C Lengauer, C. Lengauer, D Pinkel, G. Senger, H-J Lüdecke, H. -J. L�decke, J Wienberg, J Wienberg, J. Wienberg, JJ Yunis, JW Ijdo, LEM Boer de, M Djalali, M Klever, N. Arnold, P Lichter, R Avarello, R Stanyon, R Stanyon, RA Wells, T Cremer, T Ried, T. Cremer, U Trautmann, U. Claussen, Z Gelman-Kohan   +32 more
core   +1 more source

The Role of RNA in DNA Breaks, Repair and Chromosomal Rearrangements

Biomolecules, 2021
Incorrect reparation of DNA double-strand breaks (DSB) leading to chromosomal rearrangements is one of oncogenesis’s primary causes. Recently published data elucidate the key role of various types of RNA in DSB formation, recognition and repair.
Matvey Mikhailovich Murashko, Ekaterina Mikhailovna Stasevich, Anton Markovich Schwartz, Dmitriy Vladimirovich Kuprash, Aksinya Nicolaevna Uvarova, Denis Eriksonovich Demin   +5 more
doaj   +1 more source

Multidirectional chromosome painting substantiates the occurrence of extensive genomic reshuffling within Accipitriformes. [PDF]

, 2015
BACKGROUND: Previous cross-species painting studies with probes from chicken (Gallus gallus) chromosomes 1-10 and a paint pool of nineteen microchromosomes have revealed that the drastic karyotypic reorganization in Accipitridae is due to extensive ...
Beiyuan Fu, Bertrand Bed’Hom, Fengtang Yang, Gauthier Dobigny, Jinghuan Wang, Kai He, Malcolm A. Ferguson-Smith, Patricia C. M. O’Brien, Vitaly Volobouev, Weiting Su, Wenhui Nie   +10 more
core   +4 more sources