Results 171 to 180 of about 2,497,717 (340)

Disruption of ovarian function and induction of apoptosis in female mice by Brefeldin A: Mechanistic insights into reproductive toxicity

Animal Models and Experimental Medicine, EarlyView.
Brefeldin A (BFA) significantly inhibits oocyte release and induces apoptosis in ovarian granulosa cells by disrupting follicular development. It downregulates proliferation‐associated genes, reduces SIRT1/SIRT6 proteins, and upregulates cell cycle inhibitors P21 and P16. Additionally, BFA impairs estrogen synthesis and affects ovarian function through
Yao Jiang, Meng Lv, Haidan Fan, Yonghua Shi, Tao Wang, Penghao Wang, Xiaolong Yuan, Fei Gao, Bin Ma   +8 more
wiley   +1 more source

TARDBP (TDP‐43) Knock‐in Zebrafish Display a Late‐Onset Motor Phenotype and Loss of Large Spinal Cord Motor Neurons

Annals of Neurology, EarlyView.
Objective Mutations in TARDBP (encoding TDP‐43) are associated with the neurodegenerative disease amyotrophic lateral sclerosis (ALS) and include familial missense mutations where there are a lack of models and mechanisms examining how they are pathogenic.
Ziyaan A. Harji, Christian J. Rampal, Esteban C. Rodríguez, Virginie Petel Légaré, Alexandra Lissouba, Sabrina Semmler, Meijiang Liao, Jay P. Ross, Guy A. Rouleau, Christine Vande Velde, Gary A.B. Armstrong   +10 more
wiley   +1 more source

Evolutionary trends in the family Curimatidae (Characiformes): inferences from chromosome banding. [PDF]

Comp Cytogenet, 2016
Sampaio TR, Pires LB, Venturelli NB, Usso MC, da Rosa R, Dias AL.   +5 more
europepmc   +1 more source

Biosynthesis of the Biphenomycin Family of Potent Antibiotics

Angewandte Chemie International Edition, EarlyView.
The complete biosynthetic pathway of the biphenomycin antibiotics is elucidated, revealing a unique enzymatic machinery featuring a bifunctional MNIO, a regioselective arginase, a B12‐dependent rSAM for C,C coupling, hydroxylation enzymology, and a metalloprotease with dual‐specificity.
Elisabeth Strunk, Alfred Lobert, Tatiana Khorovich, Katia M. Guzman Lucio, René Richarz, Maximilian Hohmann, Paul M. D'Agostino, Tobias A. M. Gulder   +7 more
wiley   +1 more source

Chromosomal G-dark Bands Determine the Spatial Organization of Centromeric Heterochromatin in the Nucleus

, 2001
Célia Carvalho, Henrique M. Pereira, João Ferreira, Cristina Pina, Denisa Mendonça, Agostinho Rosa, Maria Carmo‐Fonseca   +6 more
openalex   +2 more sources

Methotrexate-induced increase in gap formation in human chromosome band 3p14 [PDF]

, 2008
A Markkanen, Kristiina Heinonen, Sakari Knuutila, A Delachapelle   +3 more
openalex   +1 more source

Dental fluorosis in the European roe deer (Capreolus capreolus): A review of the pathological changes in the enamel of fluorotic cheek teeth and the abnormal pattern of dental wear in affected dentitions

The Anatomical Record, EarlyView.
Abstract This article reviews the pathological changes in the enamel of permanent mandibular cheek teeth and their sequelae in European roe deer from regions polluted by anthropogenic fluoride emissions. The primary (developmental) changes of fluorotic roe deer enamel are hypomineralization and microstructural aberrations, including enamel hypoplasia ...
Uwe Kierdorf, Horst Kierdorf
wiley   +1 more source

Impact of chromosomal aberrations detected by chromosome banding analysis in symptomatic Waldenström's macroglobulinemia. [PDF]

Ann Hematol
Ito K, Kitagawa T, Harada K, Hirano K, Sekiguchi N.   +4 more
europepmc   +1 more source

Lymphocyte malignancy and chromosome 14: structural aberrations involving band q11 [PDF]

, 1986
Nanette Clare, D Boldt, G Messerschmidt, P Zeltzer, K Hansen, L Manhoff   +5 more
openalex   +1 more source

Reduction of Ribonucleotide Reductase Subunit RRM2 Potentially Impairs Gut Function of Woody Breast Broilers

Animal Research and One Health, EarlyView.
Woody breast compromises meat quality leading to reduced consumer appeal. Although its causes are unclear, improvements observed with certain dietary supplements suggest that gut health may influence woody breast development. Ribonucleotide reductase subunit RRM2 is vital for mitochondrial function and gastrointestinal integrity, and alteration in its ...
Majid Shakeri, Elizabeth Ziabtchenko, Janghan Choi, Caitlin E. Harris, Richard J. Buhr, Trevor R. Mitchell, Byungwhi Kong, Hong Zhuang, Brian Bowker   +8 more
wiley   +1 more source