Results 11 to 20 of about 60,035 (243)
Calcium ions function as a booster of chromosome condensation [PDF]
Scientific Reports, 2016 Hideaki Takata +2 more
exaly +2 more sources
Distinct Roles for Condensin’s Two ATPase Sites in Chromosome Condensation
Molecular Cell, 2019 Cees Dekker +2 more
exaly +2 more sources
A novel MCPH1 isoform complements the defective chromosome condensation of human MCPH1-deficient cells. [PDF]
PLoS ONE, 2012 Biallelic mutations in MCPH1 cause primary microcephaly (MCPH) with the cellular phenotype of defective chromosome condensation. MCPH1 encodes a multifunctional protein that notably is involved in brain development, regulation of chromosome condensation,
Ioannis Gavvovidis +8 more
doaj +1 more source
The TFIIH complex is required to establish and maintain mitotic chromosome structure
eLife, 2022 Condensins compact chromosomes to promote their equal segregation during mitosis, but the mechanism of condensin engagement with and action on chromatin is incompletely understood.
Julian Haase +5 more
doaj +1 more source
eLife, 2015 The segregation of eukaryotic chromosomes during mitosis requires their extensive folding into units of manageable size for the mitotic spindle. Here, we report on how phosphorylation at serine 10 of histone H3 (H3 S10) contributes to this process. Using
Tom Kruitwagen +4 more
doaj +1 more source
A Chromatin Switch for Chromosome Condensation [PDF]
Developmental Cell, 2012 Reporting in Molecular Cell, Tanaka et al. (2012) show that the Ku heterodimer recruits the condensin complex for retrotransposon clustering in Schizosacchromyces pombe. Histone H3 acetylation on lysine 56 blocks Ku binding and modulates this regulation of genome organization during the cell cycle and in response to DNA damage.
Bilodeau, Steve, Côté, Jacques
openaire +2 more sources
Centripetal nuclear shape fluctuations associate with chromatin condensation in early prophase
Communications Biology, 2023 The nucleus plays a central role in several key cellular processes, including chromosome organisation, DNA replication and gene transcription. Recent work suggests an association between nuclear mechanics and cell-cycle progression, but many aspects of ...
Viola Introini +4 more
doaj +1 more source
Cell-Cycle Regulation of Dynamic Chromosome Association of the Condensin Complex
Cell Reports, 2018 Summary: Eukaryotic cells inherit their genomes in the form of chromosomes, which are formed from the compaction of interphase chromatin by the condensin complex. Condensin is a member of the structural maintenance of chromosomes (SMC) family of ATPases,
Rahul Thadani +4 more
doaj +1 more source
Non-linear dynamics of chromosome condensation induced by colcemid
Brazilian Archives of Biology and Technology, 2013 This study investigated the dynamical process of chromosome condensation after colcemid treatment. Two pairs of human chromosomes, #2 and #3, were highlighted for the accurate identification by fluorescence in situ hybridization (FISH).
Thiago de Salazar e Fernandes +6 more
doaj +1 more source
CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation.
PLoS Genetics, 2014 Functional links connecting gene transcription and condensin-mediated chromosome condensation have been established in species ranging from prokaryotes to vertebrates. However, the exact nature of these links remains misunderstood.
Vincent Vanoosthuyse +8 more
doaj +1 more source