Results 201 to 210 of about 1,593,998 (268)

Genome-wide association studies of body weight, body conformation traits and coat color in Gamba sheep. [PDF]

Anim Biosci
Zhang Y, Zhou H, Gesang L, Zhaxi D, Pubu C, Miao H, Zhang J, Zhao Y.   +7 more
europepmc   +1 more source

HGTScanner: Detecting horizontal gene transfer at the fine scale using whole organelle genomes

Methods in Ecology and Evolution, EarlyView.
Abstract Horizontal gene transfer (HGT) has profoundly shaped eukaryotic organellar genomes like plant mitochondria. Yet no generalized tools are currently available to efficiently characterize HGT across these genomes due to both high structural complexity and low sequence divergence compared to prokaryotic HGTs.
Liming Cai, Rachel O. Cohen
wiley   +1 more source

Epigenetic regulation and chromatin organization in cystic fibrosis airways. [PDF]

J Cyst Fibros
De Ganzó A, Chan B, Rubinstein M, Okuda K, Ribeiro CMP.   +4 more
europepmc   +1 more source

Loss‐of‐Function Variants in CCDC189 Cause Human Oligoasthenoteratozoospermia by Disrupting Sperm Flagellar and Acrosomal Architecture

Andrology, EarlyView.
ABSTRACT Background Oligoasthenoteratozoospermia (OAT), characterized by reduced sperm count, impaired motility, and abnormal morphology, is a major cause of male infertility with substantial genetic heterogeneity. However, the underlying genetic etiology remains unresolved in a large proportion of affected individuals.
Jianteng Zhou, Ghulam Mustafa, Tingting Lin, Jingwei Ye, Huan Zhang, Hanwei Jiang, Kexin Yang, Guoning Huang, Qinghua Shi   +8 more
wiley   +1 more source

Conserved lifestyle-associated chromosome architectures across mammalian symbionts

Bulgheresi S, Viehboeck T, Krause N, Weber P, O'Shea E, Noetzel V, Pende N, Goelles-Kirth H, Varoquaux N, Boccard F, Junier I, Lioy V.   +11 more
europepmc   +1 more source

A data-driven chromatin model reveals spatial and dynamic features of genome organization. [PDF]

Proc Natl Acad Sci U S A
Oliveira Junior AB, Mello MF, Oliveira RJ, Dodero-Rojas E, Brahmachari S, Contessoto VG, Onuchic JN.   +6 more
europepmc   +1 more source

Mapping the Tissue Architecture and Endothelial‐PEC Network in HAML Using Single‐Cell and Spatial Transcriptomics

Cancer Science, EarlyView.
Spatial multi‐omics mapping of hepatic angiomyolipoma reveals that PEComas tightly co‐localize with endothelial cells, which drive autophagic flux in adjacent tumor cells via a paracrine PDGFD–PDGFRB–Ras axis, establishing a compensatory survival network that operates in parallel to canonical TSC–mTOR defects.
Xinyang Liu, Yang Guo, Xuehong Tie, Yu Liu, Fuyu Li, Jingkai Liu, Xiaohang Sun, Jiajun Zhao, Feng Geng, Yingjian Liang   +9 more
wiley   +1 more source

A scaffolding element rewires local 3D chromatin architecture during differentiation. [PDF]

Nat Commun
Jerković I, Di Stefano M, Reboul H, Szalay MF, Normanno D, Paldi F, Papadopoulos GL, Szabo Q, Bantignies F, Cavalli G.   +9 more
europepmc   +1 more source

Spatial Atlas of Small Cell Lung Carcinoma Reveals Intratumoral Tumor‐State Heterogeneity and an MMP12+ Macrophage Niche

Cancer Science, EarlyView.
Spatial transcriptomic profiling of SCLC revealed marked intratumoral heterogeneity, including coexisting neuroendocrine and non‐neuroendocrine states and spatially heterogeneous hypoxia, and identified an MMP12+ macrophage population enriched at hypoxic and necrotic tumor interfaces.
Naozane Nomura, Naoe Jimbo, Takaaki Nakanishi, Yukinobu Ito, Maki Sakaguchi, Daichi Maeda, Hiroko Ikeda, Tsukasa Ueda, Hayato Koba, Seiji Yano, Isao Matsumoto, Patrick Micke, Takayuki Kodama, Manabu Shigeoka, Yu‐ichiro Koma, Masafumi Horie   +15 more
wiley   +1 more source

Coupling between adhesome assembly and 3D chromatin organization. [PDF]

PLoS One
Cammarata LV, Sengupta D, Gupta R, Uhler C, Shivashankar GV.   +4 more
europepmc   +1 more source