A low Smc flux avoids collisions and facilitates chromosome organization in Bacillus subtilis [PDF]
eLife, 2021 SMC complexes are widely conserved ATP-powered DNA-loop-extrusion motors indispensable for organizing and faithfully segregating chromosomes. How SMC complexes translocate along DNA for loop extrusion and what happens when two complexes meet on the same ...
Anna Anchimiuk +5 more
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Chromosome Organization in Early Meiotic Prophase [PDF]
Frontiers in Cell and Developmental Biology, 2021 One of the most fascinating aspects of meiosis is the extensive reorganization of the genome at the prophase of the first meiotic division (prophase I). The first steps of this reorganization are observed with the establishment of an axis structure, that
Corinne Grey, Bernard de Massy
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Chromosome organization by one-sided and two-sided loop extrusion [PDF]
eLife, 2020 SMC complexes, such as condensin or cohesin, organize chromatin throughout the cell cycle by a process known as loop extrusion. SMC complexes reel in DNA, extruding and progressively growing DNA loops.
Edward J Banigan +4 more
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The ubiquitin-proteasome system regulates meiotic chromosome organization. [PDF]
Proc Natl Acad Sci U S A, 2022 Significance Meiotic crossover recombination is required for faithful chromosome segregation and promotes genetic diversity by reshuffling alleles between parental chromosomes.
Yang X +11 more
europepmc +2 more sources
Overexpression of Tfap2a in Mouse Oocytes Impaired Spindle and Chromosome Organization. [PDF]
Int J Mol Sci, 2022 Transcription factor AP-2-alpha (Tfap2a) is an important sequence-specific DNA-binding protein that can regulate the transcription of multiple genes by collaborating with inducible viral and cellular enhancer elements. In this experiment, the expression,
Lin J +6 more
europepmc +2 more sources
Chromosome organization by a conserved condensin-ParB system in the actinobacterium Corynebacterium glutamicum. [PDF]
Nat Commun, 2020 Higher-order chromosome folding and segregation are tightly regulated in all domains of life. In bacteria, details on nucleoid organization regulatory mechanisms and function remain poorly characterized, especially in non-model species.
Böhm K +6 more
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Braiding topology and the energy landscape of chromosome organization proteins. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance SMC−kleisin protein complexes play an important role in establishing the 3-dimensional organization of DNA in cells. Leveraging coevolutionary sequence information and molecular simulations with an energy landscape optimized force field, we ...
Krepel D +4 more
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Chromosome organization affects genome evolution in Sulfolobus archaea. [PDF]
Nat Microbiol, 2022 Badel C, Samson RY, Bell SD.
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TADs are 3D structural units of higher-order chromosome organization in Drosophila. [PDF]
Sci Adv, 2018 Drosophila chromosomes are organized in a series of nanocompartments that correspond to topologically associating domains. Deciphering the rules of genome folding in the cell nucleus is essential to understand its functions.
Szabo Q +11 more
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Bacterial chromosome organization by collective dynamics of SMC condensins. [PDF]
J R Soc Interface, 2018 A prominent organizational feature of bacterial chromosomes was revealed by Hi-C experiments, indicating anomalously high contacts between the left and right chromosomal arms.
Miermans CA, Broedersz CP.
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