Results 1 to 10 of about 3,889,493 (313)
A low Smc flux avoids collisions and facilitates chromosome organization in Bacillus subtilis [PDF]
eLife, 2021 SMC complexes are widely conserved ATP-powered DNA-loop-extrusion motors indispensable for organizing and faithfully segregating chromosomes. How SMC complexes translocate along DNA for loop extrusion and what happens when two complexes meet on the same ...
Anna Anchimiuk +5 more
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Chromosome Organization in Early Meiotic Prophase [PDF]
Frontiers in Cell and Developmental Biology, 2021 One of the most fascinating aspects of meiosis is the extensive reorganization of the genome at the prophase of the first meiotic division (prophase I). The first steps of this reorganization are observed with the establishment of an axis structure, that
Corinne Grey, Bernard de Massy
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Chromosome organization by one-sided and two-sided loop extrusion [PDF]
eLife, 2020 SMC complexes, such as condensin or cohesin, organize chromatin throughout the cell cycle by a process known as loop extrusion. SMC complexes reel in DNA, extruding and progressively growing DNA loops.
Edward J Banigan +4 more
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The ubiquitin-proteasome system regulates meiotic chromosome organization. [PDF]
Proc Natl Acad Sci U S A, 2022 Significance Meiotic crossover recombination is required for faithful chromosome segregation and promotes genetic diversity by reshuffling alleles between parental chromosomes.
Yang X +11 more
europepmc +2 more sources
Overexpression of Tfap2a in Mouse Oocytes Impaired Spindle and Chromosome Organization. [PDF]
Int J Mol Sci, 2022 Transcription factor AP-2-alpha (Tfap2a) is an important sequence-specific DNA-binding protein that can regulate the transcription of multiple genes by collaborating with inducible viral and cellular enhancer elements. In this experiment, the expression,
Lin J +6 more
europepmc +2 more sources
SnapShot: Chromosome organization.
Molecular Cell, 2022 Chromosomes in higher eukaryotes are folded at different length scales into loop extrusion domains, spatial compartments, and chromosome territories and exhibit interactions with nuclear structures such as the lamina. Microscopic methods can probe this structure by measuring positions of chromosomes in the nuclear space in individual cells, while ...
R. McCord +4 more
semanticscholar +3 more sources
Organization of the bacterial chromosome [PDF]
Microbiological Reviews, 1990 Recent progress in studies on the bacterial chromosome is summarized. Although the greatest amount of information comes from studies on Escherichia coli, reports on studies of many other bacteria are also included. A compilation of the sizes of chromosomal DNAs as determined by pulsed-field electrophoresis is given, as well as a discussion of factors ...
S. Krawiec, Andrew M. Riley
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Chromosome Architecture and Genome Organization. [PDF]
PLoS ONE, 2015 How the same DNA sequences can function in the three-dimensional architecture of interphase nucleus, fold in the very compact structure of metaphase chromosomes and go precisely back to the original interphase architecture in the following cell cycle ...
Giorgio Bernardi
doaj +5 more sources
Chromosome organization by a conserved condensin-ParB system in the actinobacterium Corynebacterium glutamicum. [PDF]
Nat Commun, 2020 Higher-order chromosome folding and segregation are tightly regulated in all domains of life. In bacteria, details on nucleoid organization regulatory mechanisms and function remain poorly characterized, especially in non-model species.
Böhm K +6 more
europepmc +2 more sources
Braiding topology and the energy landscape of chromosome organization proteins. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance SMC−kleisin protein complexes play an important role in establishing the 3-dimensional organization of DNA in cells. Leveraging coevolutionary sequence information and molecular simulations with an energy landscape optimized force field, we ...
Krepel D +4 more
europepmc +2 more sources