Results 151 to 160 of about 210,847 (212)

A Personalized Haplotype‐Resolved Near‐Gapless Genome Framework for Somatic Variant Discovery in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A patient‐specific, haplotype‐resolved genome framework improves detection and interpretation of somatic variants in hepatocellular carcinoma. Using multi‐platform sequencing, the personalized assembly resolves complex regions including centromeres and MHC/HLA loci, enhances structural variant discovery, and links regulatory alterations to allele ...
Jiazheng Lin, Yao Xiao, Shuangzi Luo, Yifan Li, Wenfei Zhang, Xiaoyu Zhang, Xinyi Wang, Di Wu, Jieru Hong, Yongkun Luan, Xun Huang, Yixiu Wang, Ningbo Wu, Xiaoxiao Hu, Fei Zhao, Wei Li, Xiao Luo, Bi Shi   +17 more
wiley   +1 more source

Evidence of Nonrandom Patterns of Functional Chromosome Organization in Danaus plexippus. [PDF]

Genome Biol Evol
Kimura A, Go AC, Markow T, Ranz JM.
europepmc   +1 more source

Chromosome organization by a conserved condensin-ParB system in the actinobacterium Corynebacterium glutamicum. [PDF]

Nat Commun, 2020
Böhm K, Giacomelli G, Schmidt A, Imhof A, Koszul R, Marbouty M, Bramkamp M.   +6 more
europepmc   +1 more source

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source

Stability and gene strand bias of lambda prophages and chromosome organization in <i>Escherichia coli</i>. [PDF]

mBio
Li X, Gallardo O, August E, Dassa B, Court DL, Stavans J, Arbel-Goren R.   +6 more
europepmc   +1 more source

Mitotic chromosome organization: General rules meet species-specific variability. [PDF]

Comput Struct Biotechnol J, 2020
Beseda T, Cápal P, Kubalová I, Schubert V, Doležel J, Šimková H.   +5 more
europepmc   +1 more source

Multidisciplinary Treatment for Esophagogastric Junction Cancer From a Dutch Perspective

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Esophagogastric junction (EGJ) cancer is an increasing health burden worldwide. Over the past decade, significant advancements in centralization, multimodal treatment strategies, as well as the widespread adoption of minimally invasive surgical techniques, have led to marked improvements in perioperative outcomes and overall survival of EGJ ...
Hidde C. G. Overtoom, Suzanne S. Gisbertz   +1 more
wiley   +1 more source

Distinct Neuropsychiatric Profiles Associated With 17p11.2 Deletions and RAI1 Variants in Smith–Magenis Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Smith–Magenis syndrome (SMS) results from either a recurrent 17p11.2 deletion or pathogenic variants in the retinoic acid induced 1 gene (RAI1). While neurodevelopmental impairment and behavioral dysregulation are well recognized, systematic genotype‐stratified analyses across psychiatric domains remain limited.
Albin Blanc, Christophe Nemos, Céline Bonnet, Mathilde Renaud, Sandra Chapuis, Pauline Boiroux, Marie‐Noëlle Babinet, Caroline Demily   +7 more
wiley   +1 more source

P158: Generating advancements in longitudinal analysis in X&Y chromosome variations: Initial data from the multicenter GALAXY Clinical Data Registry and biorepository*

Genetics in Medicine Open
Susan Howell, Kayla Molison, Alexandra Carl, Nicole Tartaglia, Carol Meerschaert, Gail Decker, Ryan Brigante, Shanlee Davis   +7 more
doaj   +1 more source

Correction to: Life history and chromosome organization determine chemoreceptor gene expression in rattlesnakes. [PDF]

J Hered
europepmc   +1 more source