Results 51 to 60 of about 476,637 (284)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Condensation and localization of the partitioning protein ParB on the bacterial chromosome [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance The ParABS system is responsible for chromosome and plasmid segregation in many bacteria. A large, coherent ParB–DNA complex forms the partitioning module at the heart of this segregation machinery. Here we provide a simple theoretical model for interacting proteins on DNA to elucidate the structure ...
Chase P, Broedersz +5 more
openaire +2 more sources
Divide Precisely and Proliferate Safely: Lessons From Budding Yeast
Frontiers in Genetics, 2019 A faithful cell division is essential for proper cellular proliferation of all eukaryotic cells; indeed the correct segregation of the genetic material allows daughter cells to proceed into the cell cycle safely.
Roberta Fraschini
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Nucleic Acids Research, 2013 Abstract Filamentous bacteria of the genus Streptomyces possess linear chromosomes and linear plasmids. Theoretically, linear replicons may not need a decatenase for post-replicational separation of daughter molecules. Yet, Streptomyces contain parC and parE that encode the subunits for the decatenase topoisomerase IV.
Huang, Tzu-Wen +3 more
openaire +2 more sources
Partition of distinct chromosomal regions: negotiable border and fixed border [PDF]
Genes to Cells, 2004 Chromosomes are partitioned into distinct functional regions. For example, heterochromatin regions consist of condensed chromatin and contain few transcriptionally active genes, whereas euchromatin regions are less condensed and majority of active genes reside in the euchromatin regions.
Akatsuki, Kimura, Masami, Horikoshi
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ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function
FEBS Open Bio, EarlyView.Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley +5 more
wiley +1 more source
Bipolar localization of a chromosome partition protein in Bacillus subtilis [PDF]
Proceedings of the National Academy of Sciences, 1997 We have determined the subcellular localization of the chromosome partition protein Spo0J of Bacillus subtilis by immunofluorescence microscopy and visualizing fluorescence of a Spo0J–GFP fusion protein.
D C, Lin, P A, Levin, A D, Grossman
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A conserved mechanism drives partition complex assembly on bacterial chromosomes and plasmids
Molecular Systems Biology, 2018 Chromosome and plasmid segregation in bacteria are mostly driven by ParABS systems. These DNA partitioning machineries rely on large nucleoprotein complexes assembled on centromere sites (parS).
Roxanne E Debaugny +11 more
doaj +1 more source