Putting the genome on the map [PDF]
, 1998 The maps of our everyday lives are much more than just linear lists of place names. Instead, their colours, symbols, contours and grid lines seek to describe different types of landscape, and to depict the spatial relationships between structural and ...
Andrulis +72 more
core +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
RGFGA: An efficient representation and crossover for grouping genetic algorithms [PDF]
, 2005 There is substantial research into genetic algorithms that are used to group large numbers of objects into mutually exclusive subsets based upon some fitness function. However, nearly all methods involve degeneracy to some degree.
Crampton, J, Swift, S, Tucker, A
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GIVE: portable genome browsers for personal websites. [PDF]
, 2018 Growing popularity and diversity of genomic data demand portable and versatile genome browsers. Here, we present an open source programming library called GIVE that facilitates the creation of personalized genome browsers without requiring a system ...
Alvin Zheng +31 more
core +2 more sources
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
A conserved mechanism drives partition complex assembly on bacterial chromosomes and plasmids
Molecular Systems Biology, 2018 Chromosome and plasmid segregation in bacteria are mostly driven by ParABS systems. These DNA partitioning machineries rely on large nucleoprotein complexes assembled on centromere sites (parS).
Roxanne E Debaugny +11 more
doaj +1 more source
Genetic algorithm approach to find the best input variable partitioning [PDF]
, 1997 Conference PaperThis paper presents a variable partition algorithm which combines the quasi-reduced ordered multiple-terminal multiple-valued decision diagrams and genetic algorithms (GAs).
Kalganova, T, Strechen, N
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Genome-wide tests for introgression between cactophilic Drosophila implicate a role of inversions during speciation [PDF]
, 2015 K.L. was funded by a junior research fellowship from the National Environmental Research Council, UK (NE/I020288/1, NBAF659).Models of speciation-with-gene-flow have shown that the reduction in recombination between alternative chromosome arrangements ...
Clarke, M. +3 more
core +3 more sources
Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone +8 more
wiley +1 more source
Polytene chromosomes as indicators of phylogeny in several species groups of Drosophila. [PDF]
, 2001 BackgroundPolytene chromosome banding patterns have long been used by Drosophila evolutionists to infer degree of relatedness among taxa. Recently, nucleotide sequences have preempted this traditional method.
Baker, RH +4 more
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