Results 91 to 100 of about 187,172 (325)
Chromosome segregation in lymphocyte hybrids [PDF]
Hereditas, 2009 Chromosome segregation was studied in mouse/human and mouse/mouse T-lymphocyte hybrids, and in mouse/human, mouse/rabbit and mouse/rat B-lymphocyte hybrids. Chromosome loss was not random, it was moderate in mouse/mouse and mouse/rat lymphocyte hybrids, but extensive in mouse/human and mouse/rabbit lymphocyte hybrids.
Schroder, J +2 more
openaire +3 more sources
One‐Step Drug Screening System Utilizing Electrophysiological Activity in Multiple Brain Organoids
Advanced Science, EarlyView.This study presents a one‐step system that delivers different drug doses to brain organoids and monitors their neural activity using integrated 3D microelectrodes. By combining dose‐specific microfluidic delivery with high‐resolution electrophysiological recording, the platform enables simultaneous, real‐time screening of neural responses across ...
Hyogeun Shin +9 more
wiley +1 more source
Cell Reports, 2013 Homologous recombination leads to the formation of DNA joint molecules (JMs) that must be resolved to allow chromosome segregation, but how resolution is temporally coupled with chromosome segregation is unknown.
Joao Matos +2 more
doaj +1 more source
The microtubule cross-linker Feo controls the midzone stability, motor composition, and elongation of the anaphase B spindle in Drosophila embryos. [PDF]
, 2015 Chromosome segregation during anaphase depends on chromosome-to-pole motility and pole-to-pole separation. We propose that in Drosophila embryos, the latter process (anaphase B) depends on a persistent kinesin-5-generated interpolar (ip) microtubule (MT)
Brust-Mascher, Ingrid +2 more
core +1 more source
Advanced Science, EarlyView.Simulated microgravity induces distinct mitochondrial hyperactivation patterns‐elevated OXPHOS and MMP‐which accelerate meiosis without SAC failure but delays MTOC coalescence, leading to spindle defects and meiotic arrest. Prolonging M‐phase restores MTOC assembly and oocyte maturation.
Lei Ge +7 more
wiley +1 more source
, 2004 This paper develops a point-mutation model describing the evolutionary dynamics of a population of adult stem cells. Such a model may prove useful for quantitative studies of tissue aging and the emergence of cancer.
A. T. Natarajan +4 more
core +1 more source
A gene-derived SNP-based high resolution linkage map of carrot including the location of QTL conditioning root and leaf anthocyanin pigmentation [PDF]
, 2014 Purple carrots accumulate large quantities of anthocyanins in their roots and leaves. These flavonoid pigments possess antioxidant activity and are implicated in providing health benefits.
Cavagnaro, Pablo Federico +6 more
core +2 more sources
Resolving Chromosome Segregation in Bacteria
Microbial Physiology, 2006 Bacterial chromosomes are evenly distributed between daughter cells, however no equivalent eukaryotic mitotic apparatus has been identified yet. Nevertheless, an advance in our understanding of the dynamics of the bacterial chromosome has been accomplished in recent years by adopting fluorescence microscopy techniques to visualize living bacterial ...
Ronen, Hazan +3 more
openaire +3 more sources
Bacterial Chromosome Organization and Segregation [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Bacterial chromosomes are generally approximately 1000 times longer than the cells in which they reside, and concurrent replication, segregation, and transcription/translation of this crowded mass of DNA poses a challenging organizational problem. Recent advances in cell-imaging technology with subdiffraction resolution have revealed that the bacterial
Esteban Toro, Lucy Shapiro
openaire +3 more sources
APOL2 Stabilizes Ku80 to Confer NHEJ‐Mediated Radioresistance in Gastric Cancer
Advanced Science, EarlyView.Radiotherapy resistance in gastric cancer (GC) is often mediated by enhanced DNA repair. APOL2 is found to promote NHEJ by stabilizing Ku80, conferring radioresistance. High APOL2 correlates with poor prognosis. Formononetin disrupts APOL2‐Ku80, restoring radiosensitivity, suggesting a novel therapeutic strategy.
Dan Zu +23 more
wiley +1 more source