Results 101 to 110 of about 185,788 (293)
Multiparental mapping of plant height and flowering time QTL in partially isogenic sorghum families. [PDF]
, 2014 Sorghum varieties suitable for grain production at temperate latitudes show dwarfism and photoperiod insensitivity, both of which are controlled by a small number of loci with large effects.
Assaranurak, I +3 more
core +1 more source
Advanced Science, EarlyView.In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu +18 more
wiley +1 more source
The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregation [PDF]
, 2014 The control of chromosome segregation relies on the spindle assembly checkpoint (SAC), a complex regulatory system that ensures the high fidelity of chromosome segregation in higher organisms by delaying the onset of anaphase until each chromosome is ...
Bolanos-Garcia, Victor M., Lee, Semin
core +3 more sources
Advanced Science, EarlyView.A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui +9 more
wiley +1 more source
Progressive chromosome shape changes during cell divisions
EMBO ReportsMitotic chromosomes give genome portions the required compaction and mechanical stability for faithful inheritance during cell divisions. They are shaped by the chromosomal condensin complex.
Yasutaka Kakui +7 more
doaj +1 more source
Cell Reports, 2013 Homologous recombination leads to the formation of DNA joint molecules (JMs) that must be resolved to allow chromosome segregation, but how resolution is temporally coupled with chromosome segregation is unknown.
Joao Matos +2 more
doaj +1 more source
Chromosome Segregation: Seeing Is Believing [PDF]
Current Biology, 2005 For chromosome segregation in mitosis, each centromere directs assembly of a complex, proteinaceous structure - the kinetochore, which connects the chromosome to microtubules of the mitotic spindle. A recent study has provided important new insights into the mechanism by which kinetochores capture spindle microtubules.
openaire +2 more sources
Inberitance patterns of tetraploid Dioscorea alata varieties [PDF]
, 2009 Polyploidy is a crucial issue for yam improvement programmes. Recent studies have revealed that the basic chromosome number of the species D. alata is x = 20 and that accessions with 2n = 40, 60 and 80 chromosomes are diploid, triploid and tetraploid ...
Abraham, Kuttolamadathil +4 more
core
Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression
Advanced Science, EarlyView.This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng +8 more
wiley +1 more source
Complementary approaches to identify genes important for chromosome segregation [PDF]
, 2007 Faithful transmission of chromosomes during cell division is essential to the functioning of the eukaryotic cell. In humans, errors during chromosome segregation are correlated with diseases such as Down Syndrome and cancer.
Bjorge, Ashley +10 more
core +1 more source